Nexense

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• Nexense
• Sensors Platform
• July 2009

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Nexense

• Privately-owned company partly held by GE
  Healthcare.
• Founded in 2001 as a result of quantum leap in
  measurement technologies.
• Conducted projects for Fortune 500 companies
  including Samsung, Ford, General Motors, Johnson
  Johnson.
• Developed working products based on its advanced
  technology.
• Holds four core patents (Top rated by Taeus),
  with over 60 patents applications.

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Technology Philosophy

• Nexense developed a unique sensors platform
  capable of measuring most physical parameters
  close to molecular precision with signal to noise
  ratio that exceeds the state of the art.
• This level of accuracy enables to identify, sense
  and measure almost any parameter in different
  sites reliably and without any touch.
• The sensors platform was evaluated and defined as
  a highly promising and working technology by
  Exponent, Taues and GE due diligence team.
• Nexense has already launched medical system
  designed to treat snoring based on the
  technology.

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Nexense Medical Developments

• Night Watch- treats snoring. 75 reduction in
  snoring according to clinical studies.
• Night Watch (Plus) - treat sleep apnea. Can
  serve as sleep lab rotary.
• Baby Watch - prevents SIDS threat, bradycardia
  and fever Monitoring
• Fetal Watch- home use monitoring of fetal
  development
• Asthma Watch - early detection of an asthma
  attack and medication management
• Emergency Watch - for monitoring vital signs
  during sleep with emergency call support
• Non Invasive Sugar evaluation evaluating Sugar
  level in blood non invasively.
• Other Applications

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Nexense Developments

• Torque Sensor-Measure torque with superior
  precision to enable vehicles to increase fuel
  efficiency and reduce emissions
• Rain Sensor-Improved rain detection without the
  miscues caused by leaves and sudden changes of
  light
• Forgotten child alert for automobiles-detect
  vital signs in a switched off vehicle and trigger
  an alarm, i.e. open windows, etc.
• Seat occupancy for smart airbag
  deployment-Distinguish human presence from dead
  weight in a car seat
• Temperature Sensor
• Pressure Sensor
• Load Cell
• Flow Meter
• Others

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Nexense cell phone applications

• Nexense sensing platform can be useful for
  long distance
• Identifying of a user according to predetermined
  features.
• Monitoring of blood pressure
• Monitoring of breath, movement and heart beats.
• Early detection of asthma
• Non invasively evaluation of the level of sugar
  in blood
• Child Well Being Monitoring
• The most valuable and exclusive application
  is the monitoring of vital signs using under the
  mattresses sensors. The cellular phone can
  replace the need for human call and send these
  accurate signs to a call center or to the user
  family,

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Example- Cellular application for Vital Signs
Monitoring

• A passive sensor is placed under the mattress
  or in the area of the user.
• The sensor detects heart beats, movement and
  breathing patterns.
• The data is sent to the users cell phone
  according to any specifications, through blue
  tooth or cables and through the cell phone to any
  third party.
• This application can be useful for monitoring
  vital signs, evaluating physical condition and
  for other applications where vital signs are
  required.

Sending vital signs
Sensors Platform
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Night Watch

• Function - reduces snoring up to 75 using self
  adaptive 3N bio feedback.
• Market according to NSF 37 of adults (40)
  snore.
• Expected demand- 1,500 units per 10,000,000
  people.
• Competition - Dental appliances, Pillows, Sprays,
  Nasal valve dilators, surgical techniques.
• Clinical studies conducted by Dr. Ilan Gur
• Regulation - FDA 513G, TUV FCC approved.
• Level of development - commercialized.
• Price 275- Ex-Nexense
• M.I.I - 30 days money back guarantee
• http//www.youtube.com/watch?vRSpr5oC
  3Ko4

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Night Watch (Extreme- for Sleep Apnea)

• Function -Treats sleep apnea using 3N bio
  feedback.
• Market -3-4 of population, 12,000,000 People in
  US.
• Excepted demand - 2,500 units per 10,000,000
  people.
• Competition - CPAP (750-3,000)
• Clinical Studies Dr blonder study
• Level of development - fully developed
• Price Ex Nexense- 500

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Night Watch Function
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Clinical Studies Results (Night Watch)

• Comprehensive Clinical studies that we have
  conducted show that using Night Watch
  significantly decreases users snoring activity
  as shown in the presented diagrams.
• In addition, due to the biofeedback effect, even
  after a user stops to use Night Watch, his/her
  snoring activity remains low comparing to his/her
  snoring level before using Night Watch.
• Preliminary study indicates that Night Watch
  (extreme) treats effectively sleep apnea. The
  sleep apnea and hypopnea decreased significantly
  as well as by decreasing desaturation.

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Night Watch Night watch influence on snores per
hour per seriesClinical Study - Conducted by
Dr. ilan Gur, 2008
Snores per hour
Without Night Watch

With Night Watch
Night Watch dramatically decreases the number of
snores per hour
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Night Watch - continueClinical Study -
Conducted by Dr. Gur, 2008
TM
Snores per Series
Patiet ZV
Patiet ZV
Without Night Watch

With Night Watch
Nigh watch also significtly decreases the
snores per series
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Night Watch - continueClinical Study -
Conducted by Dr. Gur, 2008
TM
Without Night Watch

With Night Watch
Series Length
Seconds
Night Watch shorten the length of snores series
by up to 90
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Night Watch (Extreme for apnea) The Influence
of Night Watch on sleep apnea patients preliminar
y results for future study conducted by Dr.
Blonder 2008
The preliminary study indicates significant
improvement in sleep apnea as a result of using
Night Watch (Extreme for apnea)
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Core Technology Features

• One common platform is used for most physical
  measurements
• Measuring most physical parameter having a known
  relation to the propagation time of movement of
  an energy wave through a given medium
• Produces measurements in a direct digital format,
  eliminating the need to convert from analog and
  thus maintaining extreme accuracy with regard to
  the actual values being measured
• The method enables an extremely high signal to
  noise ratio that enables less mathematic analysis
  and more close to the physics Results.

Nexense Confidential
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How we measure?
Click for white paper

• Time to Frequency Conversion

1) Transmitting cyclically-repeating ultrasonic
wave from exciter to receiver through liquid
within the sensor 2) A predetermined reference
point is detected in the energy wave at the
receiver 3) A distance change will create a
change of frequency at the receiver 4) This
change in frequency is used to produce a
measurement of the physical parameter 5) The
resolution can get to 110,000,000 or about 0.1Hz
for 1MHz measured frequency, when using 1nsec
clock 10msec time, resolution is 1100,000,000
Distance changed when sensor is being pressed
Sensor

medium
Rubber cover
10mm
Receiver
Nexense Confidential
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Physical phenomena that may be measured by means
of transit time
Transit Time
Displacement
Torque
Strain
Stress
Temperature
Velocity
Core Temperature
Compositions
Vibration
Pressure
Flow
Force
Nexense Confidential
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Nexense IP

• Presently, approximately 15 Patents have been
  issued while over 50 others are pending
• US Core Patent Description Number
• High-Precision Measuring Method and Apparatus
  6,621,278 16-Sep-2003
• High-Precision Measuring Method and Apparatus
  6,856,141 15-Feb-2005
• High-Precision Measuring Method and Apparatus
  7,080,554 25-Jul-2006
• Method and Apparatus For Making High Precision
  6,984,993
• Measurements 10-Jan-2006
• Nexense is a registered trademark owned by
  Nexense Ltd.

Nexense Confidential