David Duncan

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David Duncans fMRI EEG Results
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Working memory task
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fMRI Working Memory Performance
Accuracy
Face Memory
Scene Memory
Response Time
Face Memory
Scene Memory
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EEG Working Memory Performance
Accuracy
Face Memory
Scene Memory
Response Time
Face Memory
Scene Memory
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Scene-selective Area Modulation
BOLD Signal
Enhancement
Suppression
Remember Scenes
Ignore Scenes
Passive View
Gazzaley, A. et al. Journal of Cognitive
Neuroscience (2005)
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Normal Aging
Younger
Older
Participants 18 subjects Age 23.5 years
(19-30) Education 15.6 years (12-19)
Participants 18 subjects Age 67 years
(60-77) Education 15.4 years (12-19)
Older subjects reflect normal aging
No medications, depression, dementia
Equivalent to age-matched controls on 11 tests
of executive memory function
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Within-group comparison
Younger (19-30 y.o.)
Older (60-77 y.o.)
Remember Scenes
Passive View
Remember Scenes
Passive View
Ignore Scenes
Ignore Scenes
Gazzaley, A. et al. Nature Neuroscience (2005)
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Across-Group Comparisons
Enhancement
Suppression
Older
Younger
Older
Younger
Suppression Index (Passive-Ignore)
Enhancement Index (Remember-Passive)
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R
L
R
L
Fusiform Face Area (face-selective area)
Parahippocampal Place Area (scene-selective area)
These functionally defined regions serve as
regions of interest
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Older (60-77 y.o.)
Younger (19-30 y.o.)
Remember Scenes
Passive View
Remember Scenes
Passive View
Ignore Scenes
Ignore Scenes
Gazzaley, A. et al. Nature Neuroscience (2005)
David Duncan (49 y.o.)
Remember Scenes
Passive View
Ignore Scenes
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Top-down Index Comparisons
Enhancement
Older
Younger
David Duncan
Suppression
David Duncan
Younger
Older
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Neural Basis of Top-down Deficit
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Areas of Top-down control(Face Scene
Passive)
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Quantifying Brain Volumes
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EEG Behavioral Results
fMRI Behavioral Results
Accuracy Faces Y 90, O 78 (P 0.001), DD
83 Scenes Y 92, O 81 (P lt 0.001),
DD 90 RT Faces Y 1381ms, O 1673ms (P
lt 0.005), DD1307 Scenes Y
1348ms, O 1588ms (P lt 0.05), DD1082
Accuracy Faces Y 95, O 88 (P 0.001), DD
95 Scenes Y 90, O 83 (P lt 0.001)
DD 92 RT Faces Y 1193ms, O 1302ms
(NS), DD894 Scenes Y 1304ms,
O 1366ms (NS), DD1191
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