PKA

1
Glucagon receptor (Gs)
cAMP
Liver
I-1
Phos
PP1
PKA
GS
PP1
PFK2
F 2,6 bisP
Phosphorylase kinase
Glycogen synthase
FBPase
PK
Phosphorylase
Glycolysis
Glucose export
Glycogenolysis
Gluconeogenesis
2
Adrenalin a1-receptor (Gq)
liver
Ca2
PKC
Insulin receptor
Glycogen synthase
Phosphorylase kinase
Glycogenesis
Phosphorylase
Glycogenolysis
3
Adrenalin b-receptor (Gs)
Muscle
cAMP
Phos
I-1
PP1
PKA
GS
PP1
FBPase
F 2,6 bisP
Phosphorylase kinase
Glycogen synthase
Heart muscle
Glycolysis
Phosphorylase
Note muscle isoform of PK is not
phosphorylated by PKA
Glycogenolysis
4
Insulin
IRTK
Liver
Several steps
Phos
Several steps
ISPK
Phosphatase
GS
PK
Glycogen synthase kinase
PFK2
F 2,6 bisP
PDH
Glycogen synthase
AcCoA (for biosynthethetic purposes
Glycolysis
Glycogenesis
5
Insulin
IRTK
Muscle
Several steps
Phos
Several steps
ISPK
Phosphatase
GS
Translocation of GluT4
Glycogenesis
G6P
Glucose uptake