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Adult stem cell therapy for neurodegenerative
diseases
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BrainStorm Cell Therapeutics Inc. (OTCBB  BCLI)

• BrainStorm is a leading developer of stem cell
• technologies to provide treatments for
• currently incurable neurodegenerative diseases.
• The Company is focused on developing NTF cells
  from the patient's own bone marrow in order
  to treat, Parkinson, ALS, and Spinal Cord Injury.

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Parkinson Disease
PD is a degenerative disorder of the central
nervous system (loss of dopamine-containing nerve
cells) that often impairs the sufferer's motor
skills, speech and other functions.

• Large and growing population of Parkinson Disease
  patients (4 M in the Western world).
• Heavy social burden (according to NINDS, 26B in
  the U.S. annually).
• Disease anatomy and pathology is well known,
  although causes are still obscure.
• Affects a clearly defined region of the brain,
  the substantia nigra.

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Amyotrophic Lateral Sclerosis Disease
ALS (sometimes called Lou Gehrig's disease) is a
progressive, usually fatal, neurodegenerative
disease caused by the degeneration of motor
neurons, the nerve cells in the central nervous
system that control voluntary muscle movement.

• 5,600 people in the U.S. are diagnosed with ALS
  Amyotrophic Lateral Sclerosis (Lou Gehrig's
  Disease) each year. Total 30,000 patients in the
  US. 100,000 around the world.
• Fatal progressive loss of motor neurons in brain
  and spinal cord.
• Leads to gradual loss of movement ability,
  culminating in death.
• One approved drug Rilutek (Riluzole) affords
  only an additional few months of life.
• Pressing need for new effective therapies.

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Advantage of Cell Therapy

• Cell technologies may offer a major improvement
  over medication, as they target the diseased cell
  or organ and replace it with a healthy
  alternative.

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Adult Stem Cells
Adult stem cells are undifferentiated cells,
found throughout the body after embryonic
development, that multiply by cell division to
replenish dying cells and regenerate damaged
tissues.
Adult Stem Cells (From Bone Marrow)

• Advantages
• Non tumor forming.
• More than 40 years safety record.
• Harvested from patient therapy does not
  require immunosupression.
• Unlike embryonic stem cells, the use of adult
  stem cells in research and therapy is not
  considered to be controversial as they are
  derived from adult tissue samples rather than
  human embryos.

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Brainstorms strategy
NurOwn Therapeutic Technology
Autologous Bone Marrow-derived Stem Cell Therapy
BrainStorm Patent
Into neurotrophic factors (NTF) secreting cell
BrainStorm know-how
Bone marrow aspiration
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Intellectual Property

• Trademark filed for NurOwnTM in the US
• 3 Patents pending

1. PCT covering methods of generating
   Dopamine-producing neural cells from bone marrow
   stem cells Currently in national phase (Patent
   granted in Singapore)

1. PCT covering methods of generating
   oligodendrocytes from bone marrow stem cells
   Currently in national phase

• 3. PCT covering methods of generating
  GDNF-producing cells from bone marrow stem cells
  Currently in national phase

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Business Model
cGMP Facility
Patient population
Insurance payment to medical center
Medical center purchases BrainStorm cell
processing services
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BrainStorm Financial Summary

• Stock Symbol OTCBBBCLI
• Shares outstanding 55.3M
• Current price of stock 0.1
• 52 week price range 0.07-0.76
• Market capitalization 5M
• Approximate Public Float 17M shares
• Monthly current burn rate 150K
• Seeking for 10M to complete phase I and II
  clinical trials in ALS and phase I clinical
  trials in Parkinson.

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Safe Harbor Disclaimer

• This presentation may contain certain
  forward-looking statements. All statements,
  other than statements of historical fact, that
  address activities, events or developments that
  we intend, expect, project, believe or anticipate
  will or may occur in the future are
  forward-looking statements. Such statements are
  based upon certain assumptions and assessments
  made by our management in light of their
  experience and their perception of historical
  trends, current conditions, expected future
  developments and other factors they believe to be
  appropriate.
• The forward-looking statements included in this
  presentation are also subject to a number of
  material risks and uncertainties. We caution
  investors not to place undue reliance on the
  forward-looking statements contained in this
  presentation.
• We would advise reading our annual report filed
  with the United States Securities and Exchange
  Commission on Form 10-K for a more detailed
  description of these risks.

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