Hepatitis C in Taiwan

1
Hepatitis C in Taiwan

• 0.95 in volunteer blood donors
• 90 in hemophiliacs
• 81 in parenteral drug abusers
• Chen DS, Gastroenterologica Japonica, 1991
• 2.5 in a community in northern Taiwan
• Sheu JC, Journal of Hepatology, 1993
• 71.4 Genotype 1b, which carries high risk for
  severe liver disease
• Kao JH, J Clin Gastroenterol, 1995

2
Natural history of HCV infection
3
Treatment of Hepatitis C

• Indication
• 18 y/o 60 y/o
• Persistently abnormal ALT, positive serum
  HCV-RNA, fibrosis or moderate inflammatory
  activity of liver
• Regimen
• Combined therapy with IFN ? Ribavirin or
  Pegylated IFN Ribavirin

4
Effect of combined therapy
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7
Contraindications of combined therapy