Innate

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Innate

• Toll receptors
• Complement
• Cytokines
• a and b Interferon

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Specific

• Humoral
• Antibodies
• Cellular
• T lymphocytes
• Activated macrophages

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Specific Immunity

• Specificity
• Self non-self recognition
• Memory

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Specificity

• Humoral
• Antibody
• Cell mediated
• T cell receptor

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IgMprotects bloodstream
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IgGProtects bloodstream extracellular spaces,
crosses the placenta
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IgA protects mucosal surfaces 9 grams /day
secreted Present in breast milk
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IgE Binds to mast cells Allergies Parasitic
infections
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Self Non-self recognition
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Cytokine needs Cytokine receptorReceptor needs
Signalling tailSignal has to initiate change in
gene expression
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How could phagocytic cells behave like CD8
cytotoxic cells?
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ADCC
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Bacteria that grow inside macrophages
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Activation of macrophages
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Memory
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