Immunogenetics chapter 21 pp' 620627

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Immunogeneticschapter 21pp. 620-627
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Overview

• Lines of defense
• Basic components of the immune system
• The immune system
• B cells and T cells
• Clonal selection theory
• Antibodies

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Lines of Defense
1st and 2nd lines

• Physical and Chemical
• Immune system

3rd line
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• First line of defense

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• Second line of defense
• Inflammation
• Phagocytic cells
• complement

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3rd line of defenseThe Immune System
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Summary Lines of Defense
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Immune System
B cells
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T cells
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Lymph nodes are contain high concentrations
lymphocytes
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Lets now look at the specific lymphocytes that
reside in these nodes.
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B Cell

• Humoral Immunity
• Antibody Mediated

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CLONAL SELECTION THEORY
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The Antibody
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Different classes of immunoglobulins
IgA
IgM
IgG
IgE
IgD
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Antibody Diversity

• How do we acquire so many different types of
  antibodies?
• Somatic recombination
• Junctional diversity
• hypermutations

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V J C
Antibody genes are composed of segments
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Somatic Recombination

• http//www.bio.davidson.edu/courses/Immunology/Fla
  sh/somaticrecomb.html

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T Cells
VJC (D)
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T cells classification

• Helper T Cell
• Cytotoxic T Cells
• Memory T Cells

• CD4
• CD8

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Cytotoxic T cell CD8
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Cancer cell being attacked by cytotoxic T cells
After release of perforin
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Major Histocompatibility Complex and tissue
recognition
MHC genes on chromosome 6
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Tissue Transplantation

• MHC proteins differ between individuals

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2 types of MHC

• CD8 cells recognizes endogenous antigens
• CD4 cells recognizes exogenous antigens

• MHC I
• MHC II

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Cytotoxic T Cell and MHC I
Antigen presentation
CD8 cell
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2 types of MHC

• MHC I
• MHC II

• CD8 cells recognizes endogenous antigens
• CD4 cells recognizes exogenous antigens

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Helper T Cell and MHC II
Antigen presentation
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Antibody Production and Vaccinations
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Vaccinations

• Passive vaccines
• Active vaccines

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Antibody Production
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B lymphocytes source of antibodies
Overview of T lymphocytes
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For Your Information the immune system and
allergies
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Allergic Response I.
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Allergic Response II.
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