PROPOSED NEW FACILITIES FOR PROTON

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International Registry of IORT the 2005-2008
ISIORTEUROPE effort
Marco Krengli University of Piemonte
Orientale Novara, Italy krengli_at_med.unipmn.it
www.isiort.org/htm/isiort_europe.htm
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ISIORT EUROPE Registry
Scenario in Europe 90 members (ISIORT-Europe
website) 46 active centres in Europe (Hensleys
survey 1992/2004)
Austria Belgium France Germany Great
Britain Italy Poland Serbia Slovenia Spain Sweden
Switzerland The Netherland
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ISIORT EUROPE Registry
Meetings
NOVARA (Italy), 16 APRIL 2005 PARIS (France), 29
OCTOBER 2005 ECCO 13, LEIPZIG (Germany), 8
OCTOBER 2006 VENICE (Italy), 30 NOVEMBER 2006
GEC-ESTRO Montpellier (France), 10 May 12 May
2007 ISIORT 2008 MADRID (Spain), 12-13 JUNE
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ISIORT EUROPE Registry
Rationale for a Registry

• Availability of data for
• future retrospective analyses
• designing new prospective trials
• Contribute to homogenize treatment modalities
• Motivate centres
• Increase visibility
• Promote IORT

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ISIORT EUROPE Registry
How to use the data

• All members should access the data for reading
  by using specific password
• Data should not be modifiable without specific
  permission
• Data can be used for retrospective analyses only
  after permission of the other members
• Publications rules using these data can be
  established by the participating centres

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ISIORT EUROPE Registry
Preliminary experience 2005-2008 CENTRAL DATA
REGISTRY How to access ?
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• ISIORT
• http//www.isiort.org/htm/
• ISIORT EUROPE
• http//www.isiort.org/htm/isiort_europe.htm
• MEETINGS
• BOARD
• POOLED ANALYSIS
• QA COMMITTEE
• EBM COMMITTEE
• REGISTRY
• NEW PROTOCOLS
•  
•  
• ISIORT EUROPE web site manager
• Giovanna Mantini gmantini_at_rm.unicatt.it
• Maura Campitelli maura.campitelli_at_libero.it  
• Secretary Elena Millefiorini webmaster_at_isiort.org
                                                   
     

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REGISTRY (M.Krengli, H.Marsiglia)    Main
purposes   Make data available for future
analyses Facilitate to design new prospective
trials Contribute to homogenize treatment
modalities Increase visibility of each centre
and promote IORT       General rules  
Members only will have access to the Registry
data All data will be accessible only for
reading Data will not be modifiable Data
could be used for retrospective analyses by each
member only after permission of the other
members   All ISIORT-Europe members are
invited to download the excel file and fill-in
the data of the new treatments starting January
2006.  Download Isiort Europe Registry Excel
file The filled-in file should be sent
monthly to the following address
webmaster_at_isiort.org    The complete final
file will be available with monthly updating on
the website and all ISIORT members could access
such file just using a password. The ID of each
patients will be hidden on the final file for
privacy reason.   Please contact the secretary
of ISIORT-Europe Elena Millefiorini
at webmaster_at_isiort.org for receiving your
password.
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ISIORT EUROPE Registry
Structure of the data base

• Name of the Hospital/Institution and referring
  physician
• Patient data (initials / of record, DOB, age,
  gender, KPS)
• Tumour data (site, histology, grading, TNM,
  primary/rec.
• Treatment (intent, treatment strategy, study
  protocol)
• Surgery extension, date
• IORT prior/after T removal, of fields, diam.
  applicator, bevel, type of radiation, energy,
  type of machine, total dose, reference isodose,
  bolus
• EBRT preop./postop./none, dose, fractionation,
• Chemotherapy description

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ISIORT EUROPE Registry
Structure of the data base
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ISIORT EUROPE Registry
Available data 571 cases

• University Hospital Gregorio Maranon, Madrid,
  Spain
• University of Salzburg, Austria
• University Hospital Maggiore della Carità,
  Novara, Italy

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Cases 571
ISIORT EUROPE Registry
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ISIORT EUROPE Registry
Analysis of some the technical characteristics

• Diameter of applicator
• Bevel angle
• Energy
• Dose

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ISIORT EUROPE Registry
Breast (384 cases)
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ISIORT EUROPE Registry
Breast (384 cases)
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ISIORT EUROPE Registry
Breast (384 cases)
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ISIORT EUROPE Registry
Breast (384 cases)
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ISIORT EUROPE Registry
Rectum (51 cases)
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ISIORT EUROPE Registry
Rectum (51 cases)
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ISIORT EUROPE Registry
Rectum (51 cases)
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ISIORT EUROPE Registry
Rectum (51 cases)
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ISIORT EUROPE Registry
Pancreas (20 cases)
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ISIORT EUROPE Registry
Pancreas (20 cases)
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ISIORT EUROPE Registry
Pancreas (20 cases)
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ISIORT EUROPE Registry
Pancreas (20 cases)
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ISIORT EUROPE Registry
Data base Some Comments Difficult to access,
need to download the excel file, need to
duplicate already existing dbase Only few
Centres sent the data
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ISIORT EUROPE Registry
Data base Future development Possibility to
send data in any format (excel, access, others)
to the ISIORT-EUROPE Secretariat and use a
dedicated program to analyze data and present
statistics on the website
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ISIORT EUROPE Registry
Next steps

• questionnaire for available dbases at
  ISIORT-Europe centres
• collection of data from different formats and
  fusion in a unique dbase
• availability on the ISIORT-Europe website
  (access by password) of general data with
  graphics showing the tumours treated and the
  average main technical characteristics of the
  treatments
• possibility to perform data analysis on the
  whole dbase

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ISIORT EUROPE Registry
We need your collaboration ! Thanks!