GENOMICS

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GENOMICS
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BUILDING HOUSTON BIOTECHNOLOGY
GENOMICS

• C. Thomas Caskey, M.D., F.A.C.P.
• President CEO
• Cogene BioTech Ventures
• tcaskey_at_cogentech.com
• 713.336.7858 (Kelly Sanchez, Asst.)
• 713.336.7741 (fax)

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Critical Elements to Success
GENOMICS

• Basic Research

Technology and Drug Development
Clinical Research
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Houston Initiatives

• Four Public Corporations
• Houston Technology Center
• Rice Alliance
• Enhanced Academic Transfer Offices
• Venture Capital Networking
• The Woodlands -Research Forest
• Genesis Park
• Southeast Texas BioTechnology Park

GENOMICS
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Houston Leadership

• Academic Institutions
• Scholars
• Trainees
• Research Funding
• Pharmaceutical Industry
• NASA
• Business Schools
• Law Schools

GENOMICS
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BioTechnology Industry
GENOMICS

• Review the Past
• Forecast the Future

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BioTechnology 70s and 80s
GENOMICS

• Amgen
• Genentech
• BioGene

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Technology Base70s and 80s

• Recombinant Technology
• DNA Sequencing
• Cell Biology
• Gene Transfer

GENOMICS
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BioTechnology 90s

• Gilead
• Vertex
• Immunex
• Pharmacopoeia
• Applied BioSystems
• Aurora BioSciences
• Human Genome Sciences
• Millennium
• Affymetrix
• Incyte

GENOMICS
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Technology Base90s

• Automated DNA Sequencing
• Spacial NA Hybridization
• Robotics
• BioInformatics
• High Through Put Analysis
• Combinatorial Chemistry
• Monoclonal Antibodies
• Structural Biology
• Cell Biology

GENOMICS
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BioTechnology Future0 10

• Validated Drug Targets
• Compound Safety/Specificity
• Outcome Research (Presymptomatic)
• Transcription/Translation Drugs
• Gene Therapy
• Organ Transplantation
• Stem Cell Therapy
• Vaccines (Adult Therapeutic)

GENOMICS
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Technology Base0 10

• Mouse (other) Models
• Cell Biology
• Mouse/Cell Drug Metabolism/Safety
• Regulatory Drugs
• Gene Vectors
• Stem Cells
• Immune Tolerance
• Integrated BioInformatics
• HTS
• Patient Repository

GENOMICS
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Medical Targets
Metabolism Obesity Diabetes Osteoporos
is Frail Elderly Neurology Stroke
Protection Alzheimers Affective
Disorders Macular Degeneration
GENOMICS
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Medical Targets
Cardiovascular Atria Arrhythmias Coronary
Disease MI Protection Renal
Failure Cancer Immuno Therapy Cell
Division Arrest Apoptosis Induction Immunolog
y Vaccines Tolerance
GENOMICS
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Reminders of the Past

• A Compass wont work on an Iron Clad
• Deceased Naval Commander
• TransAtlantic Sound Buoys work defer work on
  the clock
• Scientic Leadership

There is no medical use for lasers Laser
Patent Committee Why patent monoclonal antibody
technology MRC, Cambridge I conceptualized
PCR Patent Trial Witness
Why make a BIG MOUSE? Senator The Green
Monkey died Public Education Tony and I are
sorry we disturbed the Market Bill Clinton