Mitochondria

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Mitochondria
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Mitochondrial Structure (cont.)
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Mitochondrial Structure
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Mitochondrial Structure (cont.)
SUBSARCOLEMMAL MITOCHONDRIA
MITOCHONDRIA MODELED
CAPILLARY
INTERFIBRILLAR MITOCHONDRIA
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The Respiratory Chain
I NADH - CoQ Reductase Complex II Succinate -
CoQ Reductase Complex III CoQ - Cytochrome C
Reductase Complex IV Cytochrome Oxidase
ETS 12 or more different electron carriers.
Grouped into 4 complexes
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Proton - Motive Force
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Biochemical Energetics
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Cytosolic NADH H
Inner mitochondrial membrane 71 protein
Shuttle Systems
1. Glycerol Phosphate -

• Fast Twitch - (Type II)

• Results in FADH2 in matrix

2. Malate -

• Heart, liver, slow twitch

• Results in NADH H in matrix

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Translocation of ATP, ADP, and inorganic
phosphate (Pi)
Cytosolic side
Inner membrane
Matrix side
ADP 3 -
ADP - ATP antiport
ATP 4 -
H2PO4-
Pi - H symport
H
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