Metabolic Pathways

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Metabolic Pathways
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http//www.genome.ad.jp/kegg/pathway.htmlmetaboli
sm
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KEGG
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http//www.emc.maricopa.edu/faculty/farabee/BIOBK/
BioBookGlyc.html
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http//www.emc.maricopa.edu/faculty/farabee/BIOBK/
BioBookGlyc.html
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KEGG
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KEGG
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KEGG
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KEGG
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KEGG
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KEGG
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KEGG
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KEGG
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KEGG
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KEGG
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Aerobic respiration Electron transport system
http//www.emc.maricopa.edu/faculty/farabee/BIOBK/
BioBookGlyc.html
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Glyoxylate cycle adjacent reactions
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steady state flux vo with Svo 0
null space Nul(S) vo Svo 0 (same
as Clarkes Current Cone, Cv)
dim Nul(S) n - rank(S)
null space matrix K columns are the basis
vectors of Nul(S)
SK 0
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S ? for Figure 1 network (left as an
exercise)
Given S, there are algorithms/programs that
determine rank(S). Program for constructing a set
of basis vectors CONTROL (refs 29,30)
For the network in Fig 1, the null space matrix K
was determined to be the following
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Metabolic Control Analysis (MCA)
Control coefficients
Generalized summation theorems
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Relationship with basis vectors bi
Flux convex cone F (identical to Bruce Clarkes
Current Cone, Cv )
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