Genetics of Adult Lung Cancer

1
Genetics of Adult Lung Cancer
Frederic J. Kaye, M.D.
Genetics Branch, CCR, NCI and National Naval
Medical Center
2
Types of Neuroendocrine Lung Tumors
? SCLC-related non-lung tumors
3
Types of non-Neuroendocrine Lung Tumors
4
RB Tumor Suppressor Product
Cell Cycle Arrest Repress transcription
(E2F) p105 hypophosphorylated RB
Cellular Differentiation Co-activate
transcription (MyoD) p105 hypophosphorylated RB
Apoptosis p100cl RB
5
RB functions as a tumor suppressor gene in lung
cancer
6
RB/p16/cdk pathway
Inactivation of Only One Component in the
Pathway is Required for Tumorigenesis
cell cycle arrest
p16
RB
phospho
cell proliferation
RB
7
Genetic Alterations in Lung Cancer
8
Genetic events in lung cancer
?? role
Ras
ErbB
PTEN
p16
Myc
Phosphatase genes
p14/Arf
CdkCyclin
p53
RB
9
Conclusions