DFPP

1
Figure e-1.
Clinical Course of the Patient
Phenytoin
Carbamazepine
Gabapentin
Midazolam
rituximab
mPSL
Immnosuppressive treatments
DFPP
Partial seizures Tonic seizures Hiccups Apneas
Generalized seizures
Seizures
Totally unresponsive
Consciousness
Paranoia
Hallucination
Psychiatric symptoms
CSF findings
10 45 55.0 0.52
30 78 168.3 1.0
1 38 41.2 0.56
2 36 48.0 0.55
1 54 52.9 0.48
Cells (/mm3) TP (mg/dL) IgG (µg/mL) IgG index
3 46 31.5
Anti-NR1/NR2 heteromer antibodies
CSF Serum
X 320 positive
X 10 negative
Cognitive function
Hasegawa Dementia Scale-Revised
28/30
28/30
79
Total IQ (WAIS-R)
day 60
day 90
admission
day 30
day 120
Abbreviations mPSL, methylprednisolone DFPP,
double-filtration plasmapheresis TP, total
protein levels, WAIS-R, Wechsler Adult
Intelligence Scale-Revised.