Hemophilia

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Hemophilia
By Samantha Duffy
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Hemophilia is an inherited disorder that causes
abnormal bleeding which you can die from. There
are two types of hemophilia including hemophilia
A and hemophilia B.
Results from a deficiency of a plasma protein
called factor VIII- which helps blood to clot.
This is the most common type of hemophilia where
85 of people who have hemophilia have this type
of hemophilia.
Hemophilia A (classic hemophilia)
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Hemophilia B (christmas hemophilia)
Results from a deficiency of factor IX which is a
plasma protein that helps blood to clot. Only
about 15 of people with hemophilia have
hemophilia B.
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Hemophilia is a genetic disease linked to a
defective gene on the x chromosome. So if your
mother is a carrier, and your father is normal,
and you have a boy. Then the boy will have a 50
chance of getting hemophilia. If they have a
girl. Then the girl will have a 50 chance of
being a carrier. The reason the girl doesnt get
hemophilia is because the gene is passed on in
the x-chromosome and if the mother gives the girl
a disease linked x chromosome, and the father
gives her a good x chromosome, than they cancel
out and she will be a carrier.
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About 70 of people who have hemophilia can trace
it back through their family for many
generations. In about 30 of newly
diagnosed infants with hemophilia, no other
family member can be found with the disease. In
such cases their has been a mutation in the
factor VIII or factor IX gene, which helps to
clot blood.
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Gene Therapy
Gene therapy is a novel form of disease
treatment because the active agent in a sequence
of DNA instead of the proteins or small molecules
that are currently used as drugs, said Dr. High
DNA