Neuroendocrinology

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Neuroendocrinology

• Michael Gottschalk, M.D., Ph.D.

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Figure 1
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Coronal View of Hypothalamic Nuclei
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Figure 1
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Figure 2
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Anatomy of the Hypothalamus and Pituitary
Figure 3
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Hypothalamic-Pituitary Axis
Figure 4
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• Corticotropin Releasing Hormone (CRH)
• 41 amino acid poylpeptide
• CRH release in response to pain, hypovolemia and
  tissue injury
• CRH binds to pituitary CRH receptors

7 membrane spanning CRH receptor
Figure 5
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Figure 6
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Circadian Secretion of Cortisol
Figure 7
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Proopiomelanocortin (POMC)
Figure 8
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TSH Receptor
Figure 9
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Hypothalamic-Pituitary Thyroid Axis
Figure 10
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Hypothalamic Pituitary Ovarian
Axis
Figure 11
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Menstrual Cycle
Figure 12
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Diagnostic Utilization of Releasing Hormones
T4 TSH
Normal Normal
Decreased Increased
Decreased Decreased or normal
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Normal
Hypothalamic Failure
Pituitary Failure
Figure 13
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