BIOC 462B: METABOLIC BIOCHEMISTRY

1
BIOC 462B METABOLIC BIOCHEMISTRY
www.elmhurst.edu/chm/vchembook/640reviewmetab.htm
l
2
462B COURSE PERSONNEL
FACULTY Don Bourque Tsu-Shuen Tsao Marc
Tischler (course coordinator) TEACHING
ASSISTANTS Joseph Boyd PhD candidate BMB Katie
White PhD candidate BMB PRECEPTORS Lindsey
Hutts senior BMB James Spawn senior MCB
The course homepage is linked from the topmost
navigation bar of the course D2L site. Students
are required to carefully read the policies on
the course website and are responsible for
understanding all the expectations and policies.
Students may contact us for clarification
3
462B OFFICE HOURS
4
DISCUSSION SESSIONS
Working on change due to lack of presentation
technology
462b-honors-offering
5
DISCUSSION ASSIGNMENTS

• to be facilitated by Dr. Tsao or Dr. Bourque
  (see schedule)
• mostly involve powerpoint presentations by
  teams of 2-4 students
• week 1 review presentation format distribute
  team assignments and presentation topics
• weeks 2,3 Dr. Tsao presentations
• week 4 student presentations commence
• Thursday sessions each have a theme (see
  schedule)
• presentations to be evaluated to generate a
  portion of the grade
• (to be discussed during first discussion
  session)
• attendance required unexcused absences will
  result in zero on quiz

6
DISCUSSION QUIZZES

• each discussion session will have a quiz at the
  end of the session with 2 questions worth 6
  points each
• quizzes given at end of session based on that
  days presentation
• 11 total quizzes with maximum of 10 per student
  (no quiz on day of presentation)
• two lowest quiz grades dropped except grade of
  zero cannot be dropped for an unexcused absence

7
EXAMS

• four 50-minute exams (see schedule)
• exam 4 during final exam period
• no exam grades dropped
• exams to be taken at scheduled times
• students unable to take exam as scheduled MUST
  contact Dr. Tischler prior to start of the exam
• if absence is planned (e.g., an interview)
  documentation must be provided and Dr. Tischler
  advised as far in advance as possible
• make-up exams will not be offered without
  acceptable documentation of an unavoidable
  absence

8
REGRADING

• submission required within 3 class periods
  after exam returned
• write regrade request on separate page attached
  to exam
• explain why more points are deserved for a
  particular question
• regrading will be done by instructor who wrote
  the question in consultation with TA who graded
  the question

CHEATING

• students will be held responsible for the
  information concerning cheating in the policies
• if clarification is required speak to the
  faculty within the first week

9
PERFORMANCE EVALUATION

• final grades expressed relative to total points
  accumulated in the course
• Exams 100 points each 400 points maximum
• Quizzes 12 points each 96 points maximum 2
  lowest grades dropped except for grades of zero
  due to unexcused absence
• Presentation 54 points
• presentations scored by faculty facilitator,
  assigned section TA and fellow students
• scoring 5A 4B 3C 2D 1E
• peer score worth 50 of the total points
  faculty 25 TA 25
• total pts 54(avg peer score2)(faculty
  score)(TA score)/20
• Grade cutoffs
• A 495 pts (90)
• B 440 pts (80)
• C 385 pts (70)
• D 330 pts (60)
• E lt330 pts (lt60)

10
INTRODUCTION TO METABOLISM

• Roles of Metabolism
• deriving chemical energy from solar energy or
  degradation of nutrients
• converting nutrients to molecules that are
  needed for cell function
• producing macromolecules (e.g., proteins,
  nucleic acids)
• synthesizing and degrading biomolecules
  required for unique cell functions

11
INTERPLAY BETWEEN AUTOTROPHS AND HETEROTROPHS
Oxygen Organic products
CO2
Photosynthetic Autotrophs
12
(No Transcript)
13
(No Transcript)
14
SEQUENCE OF COURSE TOPICS

• Exam 1 (Dr. Tsao)
• bioenergetics
• carbohydrate metabolism glycolysis,
  gluconeogenesis, pentose pathway, glycogen
• signal transduction
• metabolic regulation
• Exam 2 (Dr. Tsao and Dr. Bourque)
• pyruvate dehydrogenase, citric acid cycle,
  glyoxylate cycle
• lipid metabolism digestion, fat oxidation,
  ketone body metabolism
• oxidative phosphorylation
• Exam 3 (Dr. Bourque)
• photophosphorylation
• amino acids oxidation, synthesis
• carbohydrate biosynthesis
• Exam 4 (Dr. Tischler)
• lipids fat synthesis, cholesterol,
  eicosanoids, lipoproteins
• lipophilic hormones