HRT after breast cancer

1
HRT after breast cancer

• Is it Safe ?

2
Why?

• Controversy
• Observational studies misleading
• Further studies may not get ethics approval

3
.

• Habits study conducted in sweden
• Published in Lancet february 2004

4
study

• RCT
• Postmenopausal women
• Tis -stage 2 breast cancer
• One group given HRT
• Follow up 2.1 years
• Any new breast cancer event

5
results

• Total 345 patients
• 26/174 on HRT developed CA
• 7/171 (not on hrt) developed ca
• Trial stopped

6
strengths

• Randomised
• Prospective
• Well defined clinical goal

7
weakness

• Unblinding
• Lack of placebo controls
• No defined restaging

8
characteristics
9
recommendation

• HRT increases risk of breast cancer in post
  menopausal women
• Alternative non hormonal options should be
  considered when treating post menopausal symptoms