Amines

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Amines
Ibuprofen

• April 6, 2005
• Compounds
• By Names of Team Members

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Goals Amines

• What amines are.
• What things in our life contain amines.

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Amines, what are they?

• Organic molecules that correspond to ammonia,
  NH3, in which one, two, three, or all three of
  the hydrogen atoms have been replaced by R groups
  (chains or rings) of carbon atoms (with their
  associated hydrogen atoms).

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How do we recognize an amine?

• Amine group is a nitrogen atom with two bonded
  atoms or groups.
• Ammonia molecule
• The names for many amines end in ine.
• Ex CH3NH2 is called methylamine.

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Physical properties

• High melting points and boiling points compared
  to similar alkanes.
• High solubility in aqueous solutions.
• Amines have odors that disgust us.

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Amines that stink

• The bad smells come from amines that contain two
  amino nitrogen atoms or diamines.
• Rotting fish produce trimethylamine (CH3)3
• Others things that smell because of amines are
  Urine, bad breath, and semen.

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Structure of amines

•  

• N atom bonded either to C or H atoms
• Both the C-N and the N-H bonds are polar

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Everyday amines

• Antidepressants
• Prozac and Paxil
• These two drugs are mood-altering
• They increase the concentration of serotonin,
  which is an amine.

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Everyday amines

• Nicotine
• Consists of molecules of one pyridine ring and
  one pyrrolidine ring joined by a single bond.
• It raises heart rate, blood pressure, and
  adrenaline, which is an amine.
• Nicotine is addictive.

Nicotine
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Everyday amines

• Caffeine
• Contain four nitrogen atoms with one six-membered
  ring and one five-membered ring
• Remains in the bloodstream twice as long as
  nicotine.
• The lethal does of caffeine is 10 grams or about
  100 cups of coffee drank quickly.

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Drugs

• Cocaine
• Nitrogen containing compound
• Highly addictive
• Stimulant and a depressant.

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Drugs

• Cocaine
• The ionic form of cocaine is snorted by users
• It dissolves in the watery mucus membranes.
• Cocaine hydrochloride is a ionic solid and
  consequently has a high melting point. (about
  200o celcius).

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Drugs

• Cocaine
• Cocaine effects the level of the neurotransmitter
  dopamine.
• Half life 45 minutes

cocaine
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Drugs

• Cocaine
• Fun facts
• Cocaine also works as a local anesthetic and was
  used by dentists in the early 19th century.
• Sigmund Freud advocated using cocaine for
  depression and used it himself.
• Until 1903 cocaine was used in small
  concentrations in Coca-Cola

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Drugs

• Amphetamines
• An illegal drug.
• In an amphetamine the NH2 group is bonded to a
  carbon chain that ends with a benzene ring.
• Its structure is similar to adrenaline.
• Amphetamines increases heart rate, energy level,
  drive, and mood for a short period.

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Drugs

• Methamphetamines
• Half life is about 12 hours.
• Has a greater psychological effect than
  amphetamines.
• Ecstasy is derivative of methamphetamines.

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Amines used as drugs

• Painkillers
• Most painkillers are nitrogen containing organic
  compounds.
• Acetaminophen (acetaminophen) is known
  commercially as Tylenol, Panadol, and Datril.
• Combines acidic acid with an amine consisting of
  a nitrogen group bonded to a benzene ring.
• It is analgesic and an antipyretic meaning it
  relives pain and fevers.

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Drugs

• Painkillers
• Aspirin is an example, it contains a carboxylic
  acid group and an ester group of acidic acid
  bonded to a benzene ring.
• Aspirin is an anti-inflammatory.

Aspirin
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Drugs

• Painkillers
• Other examples are Ibuprofen also known as Advil,
  Motrin, Midol, and Nuprin.
• Is an anti-inflammatory as well a pain reliever.

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Drugs
Morphine

• Painkillers
• Morphine is also a complicated amine that relives
  pain.
• Morphine blocks nerve receptors that register the
  sensation of pain.
• Codeine and heroin are forms of morphine.

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Works cited

• http//www.chem.ucalgary.ca/courses/351/Carey/Ch22
  /ch22-1.htmlNomenclature
• www.whfreeman.com/chemistryinyourlife
• http//www.cem.msu.edu/reusch/VirtualText/amine1.
  htm
• www.amphetamines.com
• Yahoo Images http//www.yahoo.com
• Baird, Colin, Gloffke, Wendy. Chemistry in Your
  Life. W.H. Freeman and Company. New York, 2002.