Geoethics for Cryonic Revival Nanotech

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Geoethics for Cryonic Revival Nanotech BioNano
Sleeves

• Martine Rothblatt
• 4th Workshop on Geoethical Nanotechnology (GN4)

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Definition of Key Terms

• Geoethics Rules for managing the global risks
  of technology
• Cryonic Revival Nanotech Sub-cellular machines
  used to return a vitrified body to health
• BioNano Sleeves Bodies made of DNA-based and
  nanotech-based substrates

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Self-Replicating Nanotech Is Most Useful to
Extended Life
Human Body Creates 50x106 Cells Per Second
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Very Similar Situation with Recombinant
Biotechnology
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Huge Increase in Practicality By Permitting
Self-Replication
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Apply Geoethical Rules of Recombinant DNA to Nano?
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The Asilomar Guidelines

• containment essential must match the risk
• use of biological barriers to limit the spread
  e.g. host-specific nonsurvivable
• physical containment,
• good microbiological practices training
• no cloning of recombinant DNAs derived from
  highly pathogenic organisms, containing toxin
  genes, or making biohazards that could not be
  contained

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Matching the Risk
rDNA HGH

• Minimal and low risk
• minimal if biohazards could be accurately
  assessed and were expected to be minimal.
• Low risk if novel biotypes but not
• change ecological behavior of the recipient
  species,
• increase significantly its pathogenicity or
• prevent treatments of any resulting infections.

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Minimal Risk Containment

• Prokaryotes, bacteriophages and other plasmids,
  experiments could be performed in minimal risk
  containment facilities when the construction of
  recombinant DNA molecules and their propagation
  involved prokaryotic agents that were known to
  exchange genetic information naturally
• Additionally, purified DNA from any source that
  performed known functions and was judged to be
  non-toxic could be cloned with available vectors
  in low risk containment facilities

Bacteriophage T4 infecting an e. coli host
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Moderate and High Risk

• The moderate risk level of containment if
  significant potential for pathogenicity or
  ecological disruption.
• High-risk containment if a serious biohazard to
  laboratory personnel or to the public.
• DNAs of species that result in new metabolic
  pathways in species, use moderate or high-risk
  containment

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Asilomar Guidance Relevant to Cryo-Bio Nano
Nano-neuron

• Unless the organism made a dangerous product,
  recombinant DNAs from cold-blooded vertebrates
  and all other lower eukaryotes could be
  constructed and propagated with the safest
  vector-host system available in low risk
  containment facilities.

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Cryo Bio Self-Replicating Nanotech Are Like
Asilomar Low-Risk Examples

• A mech analog of a rDNA
• Not banned if not toxic, which is illogical for
  cryo-bio
• Low-Risk because novel biotype but doesnt
  change ecology or ? pathogenicity
• Not Minimum Risk because unnatural replication
  method
• Not Moderate or High Risk since not high
  potential for pathogenicity, ecological harm or
  biohazard

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So, What Geoethics Is Needed for Low Risk
Self-Replicating Cryo-Bio Nanobot?

• Global Agreement That Risk Is Low
• Scientific Meetings
• Global Sharing in Benefits
• Commercial Endeavors
• 3rd Party Audit of Containment Niche-Limitation
  Protocols
• Same Facility Certification as for rDNA

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Going Forward

• Cryonic Revival Sleeve-Based Bio-Nanotech Falls
  Under rDNA Regime
• Same Issues,
• New Substrate
• Green Light to Go On with Experiments
• Just Follow Asilomar
• We Can Geoethically Remake Ourselves!

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Just Make Sure Our Cryo-Bio Nanobots Dont Fly!