Subunit Association

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Subunit Association
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A Generic Chemical Reaction
A BC ? AB C
Collision 2
Transient bond formation
B
A
A
B
C
C
Step 1
B
A
B
A
C
C
Step 2
Bond breaks
A REACTION OCCURS!
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A Generic Chemical Reaction
A BC ? AB C
Collision 3
A and C repel each other
A
A
B
C
Step 1
A
Step 2
A
rebound
NO REACTION!
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A Generic Chemical Reaction
A BC ? AB C
Collision 1
Transient bond formation
B
A
C
B
A
C
Step 1
B
A
C
Step 2
B
A
C
rebound
NO REACTION!
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A Generic Chemical Reaction Catalyzed by an Enzyme
A BC ? AB C
A


A
?
C
B
B
C
Enzyme active site
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A Generic Chemical Reaction Catalyzed by an Enzyme
A BC ? AB C
?
A
A
C
C
B
B
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A Generic Chemical Reaction Catalyzed by an Enzyme
A BC ? AB C
?
A
A
A
?
C
C
C
B
B
B
?

C
B
A
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How Enzymes Work
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Hallmarks of Enzyme Activity
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Hallmarks of Enzyme Activity