Makerere UniversityJohns Hopkins University Research Collaboration MUJHU Care Ltd

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Makerere University-Johns Hopkins University
Research Collaboration MUJHU Care Ltd

• Philippa Musoke
• MUJHU and
• Department of Paediatrics and Child Health,
  School of Medicine

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The MU-JHU CARE Mission To improve the
health status of families infected and
affected by HIV/AIDS through research,
training, prevention and care
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MU-JHU CARE Background

• MU-JHU has conducted NIH supported HIV research
  prevention activities in Uganda since 1988
• The initial Collaborative partnership was with
  Case Western Reserve University before the PIs
  moved to Johns Hopkins University
• In 2006, MU-JHU Research Collaboration was
  incorporated as a legal entity (MU-JHU CARE LTD)
  to enable MU-JHU to seek and receive direct
  Program funding to support its families

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MU-JHU Research ActivitiesFocus Prevention of
mother to child HIV transmission
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The MUJHU HIVNET 012 Trial Results -1999

• 50 reduction in HIV transmission when mothers
  and newborns received Nevirapine compared to
  those who got Zidovudine (16 vs 26 at 18 mths)
• Nevirapine was safe and well tolerated
• The Single Dose NVP regimen has formed the basis
  for the rapid expansion of PMTCT across the
  developing world
• However, there are concerns about emergence of
  resistance after sd NVP in mothers and infants

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Other Important Studies

• NVP repeat pregnancy study
• HIVIGLOB/SWEN study done in Uganda, India, and
  Ethiopia
• HPTN 046 study infant NVP prophylaxis
• HPTN 027-neonatal ALVAC vaccine trial
• P1060 /ILA HAART in NVP exposed and non
  exposed children

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Programs

• PMTCT program in partnership with
• Mulago hospital, Rubaga and Mengo hosp
• MTCT plus comprehensive HIV care and treatment
  program

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Challenges

• Multiple studies with need for ongoing training
  including GCP
• IRB submission and responses in a timely manner
• NDA submission and responses
• Competing with multiple activities
• Internet stability

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Future Plans

• Microbicide studies
• TB vaccine studies
• Closer links with school of medicine
• Strengthen grants training and management
• Provide a family HIV care and treatment center