K 305

1
K 305 21 May 03
2
E-C coupling in mammalian heart
3
E-C Coupling in the Heart

• L-type Ca channel or DHPR
• a1c or CaV1.2 subunit
• SR Ca release channel or RyR
• SERCA2A
• Phospholamban (PLB)
• NCX1.1

4
(No Transcript)
5
Kinesiology 305 (03-2)Human Physiology I AQ5016
Course Outline     Respiratory Section Website
Schedule of Lectures         



     
6
E-C Coupling in the Heart

• L-type Ca channel or DHPR
• a1c or CaV1.2 subunit
• SR Ca release channel or RyR
• SERCA2A
• Phospholamban (PLB)
• NCX1.1

7
E-C coupling in mammalian heart
8
E-C Coupling in the Heart

• L-type Ca channel or DHPR
• a1c or CaV1.2 subunit
• SR Ca release channel or RyR
• SERCA2A
• Phospholamban (PLB)
• NCX1.1

9
E-C coupling in mammalian heart
10
E-C Coupling in the Heart

• L-type Ca channel or DHPR
• a1c or CaV1.2 subunit
• SR Ca release channel or RyR
• SERCA2A
• Phospholamban (PLB)
• NCX1.1

11
E-C coupling in mammalian heart
12
E-C Coupling in the Heart

• L-type Ca channel or DHPR
• a1c or CaV1.2 subunit
• SR Ca release channel or RyR
• SERCA2A
• Phospholamban (PLB)
• NCX1.1

13
E-C coupling in mammalian heart
14
Regulation of E-C Coupling

• SNS via the adrenergic b1 receptor
• Gs- AC and PKA and phosphorylation of
• DHPR (b subunit) - increasing open probability
• phospholamban -increasing SERCA2A activity
• TnI - increasing off loading of Ca from TnC
• RyR - increasing fractional release