Kappa gene expression

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Kappa gene expression
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MVA Fig. 28.39
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H-gene expression
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Recombination signal sequences
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When ss DNA is generated
Extra nucleotides can also be added
Nucleotide addition during joining
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Somatic variation
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Secreted vs. membrane forms of IgM
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Secretory pathway
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Class switching by alternative processing
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Class switching by alternative processing
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cis-acting sites
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Allelic exclusion (only in B and T cells)
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Model of allelic exclusion
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Class switching
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Possible mechanisms for DNA rearrangements
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