Hope all is well this morning, I'm just hearing about your luggage''''your abstract title for Cold S

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Dosing 6MP with pharmacogenetics
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NB TPMT genotype did NOT affect relapse, in
context of individualizing dose based on TPMT
Relling et al, Blood, 2006
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Evans et al, SJCRH, 2000
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(No Transcript)
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V
? Diarrhea, leucopenia
Nature Reviews Cancer 2001
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(No Transcript)
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Polymorphisms in MTX targets and transporter
MTHFR modifier
MTHFR C677T
TYMS target
RFC uptake
MTX
MTX
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Greater oral mucositis index (OMI) after low-dose
MTX among BMT patients with mutant MTHFR C677T
genotypes than among patients with C677C genotypes
50
40
10 of patients
Ulrich et al Blood 98231-4, 2001
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But MTHFR did not Affect Toxicity after HDMTX
(with LV)
Variant
Relling et al
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Evans et al, SJCRH, 2000