Hormone Structure and Function

1
Hormone Structure and Function
Is a hormone the message or the messenger?
Perhaps Both?
2
Different Molecular Structures
Insulin
Message
3
Episodic Hormone Secretion Pulses
Frequency and Amplitude
Messenger
4
Biopotency
What information is necessary to assess the in
vivo biopotency of a hormone?
How can structure effect synthesis, secretion,
and ½-life?
5
Biopotency
hCG
hLH
6
Biopotency
7
Steroid Structure
5a
5b
8
Steroid Structure
9
Antagonists
10
Antagonists
hCG
deglycosylated hCG
11
Thyroid Hormones
t1/2 T4gtT3gtgtrT3
12
Thyroid Hormones