Title: Medical abortion by mifpristone at home
1ESC Budapest Seminar 2003
Dr E. AUBENY, Paris FIAPAC
2Medical abortion by mifepristone at home ?
Present protocol of medical abortion by
mifepristone is
Efficacy rate 95.4
3Medical abortion by mifepristone at home ?
- Definition
- What is medical abortion at home ?
- It is the possibility to skip the visit to the
hospital in order - to take misoprostol (Cytotec), and take it at
home -
- This possibility would make medical abortion
easier
Dr E. AUBENY - Fiapac Paris
4 1- Is a non-hospitalisation after misoprostol
(Cytotec) possible from a medical point of
view?
51983 - 1987 abortion by mifepristone only
6Since 1987 abortion by mifepristone
prostaglandins
7Why women stay at the hospital after
prostaglandins
FEAR
8Why women stay at the hospital after
prostaglandins
- Fear of prostaglandins (problem with
sulprostone)
Replaced in 1992 by 400 µg misoprostol (Cytotec)
taken orally
? For 20 years, daily use all over the world to
prevent gastric ulcers when taking AINS
9Why women stay at the hospital after
prostaglandins
Misoprostol (Cytotec)
Suspicion towards misoprostol taken orally as a
drug for abortion is not justified
No need for a medical supervision in hospital
10Why women stay at the hospital after
prostaglandins
- Fear of haemorrhage at the time of expulsion
French and American trials show ? few
haemostatic aspirations 0.3
? late bleeding 10 to 15 days later
? few non-cataclysmic bleeding at the time of
expulsion
R. PEYRON, 1995 Spitz, 1999
11Why women stay at the hospital after
prostaglandins
- Fear of haemorrhage at the time of expulsion
Center Orthogénie Broussais few hemorrhages non
cataclysmic
Dagousset I non published
12Why women stay at the hospital after
prostaglandins
- Fear of haemorrhage at the time of expulsion
the 3-hour hospitalisation is not logical 40 of
women expel outside of the center
13Why women stay at the hospital after
prostaglandins
- Fear of haemorrhage at the time of expulsion
To summarise
? No more than one hour drive from the center
? Possibility to go to the centre day and night
14Why women stay at the hospital after
prostaglandins
- Fear of secondary effects
with 4OO µg misoprostol orally, they are
endurable
only 20 of non morphinic pain killers, they
can be taken at home
non frequent treatment, they that can be taken
at home
15Why women stay at the hospital after
prostaglandins
Fear of haemorrhage
Fear of secondary effects
Fear ofprostaglandins
To summarise, the French and U.S trials show from
a medical point of view that
Hospitalisation is not justified, neither by the
fear of prostaglandins,nor by fear of
haemorrhages, nor by fear of secondary effects
16 Medical abortion by mifepristone at home ?
Foreign experiences go in the direction of
misoprostol at home
Ambulatory medical abortion
.
17Medical abortion by mifepristone at home ?
2 Is a non-hospitalisation after misoprostol
(Cytotec) possible from a
psychological point of view?
18Acceptability by women
French trial
?
?
120 women chose to go home
Dagousset I. and al, in press
19Medical abortion by mifepristone at home ?
Acceptability by women
-
- Results for 120 patients
- No major undesirable event
- Acceptance of the protocol 100
- Anxiety (valued by the number of phone calls)
- - 1 call 23 patients, 2 to 3 calls 3
patients - - no call 94 patients
- Use of pain killer 47 patients
-
98.5 of patients find the procedure
acceptable 77.5 of patients would recommend
it more privacy
Dr E. AUBENY - Paris, Fiapac
20 3. Conclusion
21Conclusion
New possibility for women They must
be able to choose it
Dr.E. AUBENY - Paris, Fiapac