A GENESIS Model of Dendrodendritic Feedback Inhibition of the Mitral Cell in the Olfactory Bulb'

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A GENESIS Model of Dendrodendritic Feedback
Inhibition of the Mitral Cell in the Olfactory
Bulb.
Simon OConnor and Tim Jacob, School of
Biosciences, Cardiff University, Cardiff CF10
3US, UK (simon.oconnor_at_btinternet.com)
Intracellular recording from Mitral cell
Olfactory Bulb Electrophysiology
Dendrodendritic Reciprocal Synapses
Feedback Inhibition
50 C.P.S.
Adapted from Mori, K., Kogure, S., and Takagi,
S.F. (1977) Alternating responses of olfactory
bulb neurons to repetive lateral olfactory tract
stimulation. Brain Res. 133, 150-155.
Current injection into Mitral Cell via
Lateral Olfactory Tract
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Olfactory Bulb Neuropharmacology
G-Coupled Norepinephrine Receptors
Adapted from Trombley, P.Q. Westbrook, G.L.
(1990) Excitatory Synaptic Transmission in
Primary Cultures of Rat Olfactory Bulb. J.
Neurophysiol. 64, 598-606.
Mitral Cell
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Bhalla and Bower ModelOlfactory Bulb Cells
Specimen output from The depicted Mitral Cell
Simulation
Sketch of Mitral Cell representation In an
implementation of the Bhalla and Bower model By
David Beeman
Bhalla, U.S. and Bower, J.M. (1993). Exploring
parameter space in detailed single neuron
models Simulations of the mitral and granule
cells of the olfactory bulb. J. Neurophysiol. 69
1948-1465.