Ethanol

1
Ethanol
Ethanol Acetaldehyde PEth ROS Others
RTK
GPCR/ G-proteins
Src
Acetaldehyde
Ras-raf
PKC
PEth
ROS , others
MEK 1/2
Acetate
p38 MAPK
p42/44 MAPK
JNK1/2
Caspases
p42/44 MAPK
JNK1/2
?
p38 MAPK
MSK 1/2
Transcription factor/activation (NFkB,
AP1, CREB etc.)
Histone/chromatin modification (acetylation,
phosphorylation etc.)
NUCLEUS
Apoptosis Inflammation Proliferation
Differentiation