National Taipei University of Technology

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One Place for the Answers You Need

• National Taipei University of Technology
• Taipei, Taiwan

Doreen Tan . Product Sales Manager , Life Science
. Elsevier ST (APAC).
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A Better Way to Get Answers

• Scientific information is scattered in disparate
  locations and must be accessed by multiple
  applications.
• Scientists do not fully utilize applications and
  electronic content
• Too time consuming
• Too many applications to learn
• The research of scientists will be more
  productive if all content is centrally
  integrated, indexed and linked
• With one query, DiscoveryGate connects you to
  many information sources, giving you the
  information you need to decide what to do next.

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DiscoveryGate - A better way to get answers

• The first stop for chemistry facts and details
• The portal to best-of-breed databases in
  chemistry
• The integrated tool to enable researchers to find
  relevant scientific details
• The most effective way to provide the most
  chemistry data to the most researchers

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Comprehensive chemistry
17 premier chemistry databases
Authoritative Major Reference Works
More than 16 million compounds
More than 11 million reactions
More than 300 million associated facts data
Links to full text to over 15,000 journals and
patent archives
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Key Content

• Primary Content - Original Literature Sources
• Publications containing detailed descriptions,
  methodology and scientific results (journals,
  patents, proprietary original work)
• Secondary ContentDatabases
• Synthesis, bioactivity, physical property,
  metabolism, toxicity and sourcing databases
• Tertiary ContentAuthoritative Reference Works
• Well regarded core knowledge summarizing a
  particular topic

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Key Content Sources
20 Content Chemistry Reference CrossFire
Beilstein CrossFire Gmelin Bioactivity MDL Data
Drug Report MDL Metabolite Database MDL
Toxicity Database NCI/AIDS MDL Comprehensive
Medicinal Chemistry Synthetic Methodology ChemInfo
rm Reaction Library Current Synthetic
Methodology Derwent Journal of Synthetic
Methods MDL ORGSYN Database MDL Solid-Phase
Organic Reactions MDL Reference Library of
Synthetic Methodology Chemical Sourcing and
Logistics MDL Available Chemicals Directory MDL
Screening Compounds Directory

• 10 Content
• Academic Press
• ACS
• Allen Press
• Biochemical Journal
• Blackwell Synergy
• Catchword
• Cell Press
• European Patent Office
• Elsevier Science
• HighWire Press
• Karger
• Kluwer
• Nature
• JAMA
• Ovid
• PubMed
• RSC

• 30 Content
• Science of Synthesis
• Houben Weyl Methods of Transformations
• Comprehensive Asymmetric Catalysis
• Comprehensive Organic Functional Group
  Transformations
• Encyclopedia of Reagents for Organic Synthesis

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Access to Integrated Content from a Single
Interface

• Chemistry Reference
• CrossFire Beilstein
• CrossFire Gmelin
• ISI Index Chemicus
• Bioactivity Pharmacology
• MDL Data Drug Report
• MDL Metabolite Database
• MDL Toxicity Database
• National Cancer Institute Databases
• MDL Comprehensive Medicinal Chemistry
• xPharm
• Chemical Sourcing and Logistics
• MDL Available Chemicals Directory
• MDL Screening Compounds Directory

• Synthetic Methodology
• ChemInform Reaction Library
• Current Synthetic Methodology
• Derwent Journal of Synthetic Methods
• ORGSYN Database
• MDL Solid-Phase Organic Reactions
• MDL Reference Library of Synthetic Methodology
• ISI Current Chemical Reactions
• Integrated Major References Works
• Patent sources
• Derwent World Patent Index

• Structures are indexed in Compound Index.
• User links out to 3rd party application to view
  detailed data

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Profiling on Each Contents
Contents Properties Reaction Catalog Info. Bioactivity Toxic Info. ADME
Beilstein?Gmelin ? ? ? ?
Compound Index (Beilstein?Gmelin???) ? ? ? ? ? ?
Synthetic Methodology ?
Chemical Sourcing (ACD?SCD) ?
?????3? CMC, MDDR, NCI ?
Toxicity ?
Metabolite ? ?
IMRW(????) ?
Compound Index????????
???????? ?Compound Index???????? ?Beilstein?Gmelin
???????? ?IMRW?????????
Compound index????????????????????????????????????
??????????????DB??????
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DiscoveryGate features
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Find relevant records using known properties
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Search across an index of structures and
properties

• Select the Compound Index and perform a structure
  and property search
• Returns summary data from the primary source
• Click directly into primary databases for more
  detail

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Focused database searches
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Single view of results from multiple sources

• Search across an index of compounds from MDL and
  selected 3rd party databases
• Search by property and structure
• Currently 8 million unique structures
• Can be filtered by property type
• A unique map of which compounds detailed data
  exist
• Interlinks to the underlying specific database
  for detailed review of the underlying data

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Extend research to the full text

• Leverage existing subscriptions by linking
  automatically from citations to corresponding
  full text and patents. Librarians can
• Manage links on DiscoveryGateor
• Point to internal library link resolver

• All bibliographic AND patent references are
  hyperlinked
• Always view the primary literature where you have
  subscribed access

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Scopus Linking

1. Review a compound list excerpted in CrossFire
   Beilstein from a citation found in Scopus
2. View additional data from the CrossFire Beilstein
   Database for a compound of interest via
   DiscoveryGate (or Commander if on PC and
   preferred)

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http//gateway.discoverygate.com

• LIVE DEMO

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What is fact data?

• Cited experimental value from journals
• The journal list is not fact data
• Fact data is not required, because we always
  refer to original articles?!

• You have to wait for several days to obtain
  journals from other libraries.

Save Time and Money!
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Example Fact Data from DiscoveryGate / Beilstein
UV/Vis Plural maximum absorbance with
corresponding molar absorption coefficient are
available.
Pharmacological data Apoptosis inhibition data
with experimental summary.
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Help!
I cannot log into SciFinder Scholar always! Why
not?
SciFinder Scholar has the limitation of access
number. DiscoveryGate has NOT such limitation!
Every time, Every Day available.
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SciFinder is Better
I need the latest information about Taxol.
Daily updates, collection from all chemical
journals
I need the patent information for Taxol.
SciFinder collects patent information from 50
patent offices in the world.
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Have to use DiscoveryGate-Fact data will help
your searching! -
Sulfone (not sulfonic acid) with less than pKa
11. What kind of X and Y are suitable?
???????????????Beilstein???!
DiscoveryGate has not Auto Fix! The ambiguity
reaction search is available DiscoveryGate, not
SciFinder.
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DiscoveryGate vs. SciFinder

• Which is better?

DiscoveryGate Fact data, Reference Value, no
access limitation number Beilstein, Gmelin
Reported measured properties, and reaction data
SciFinder Scholar Exhaustive Bibliographic data
with access limitation number Chemical Abstracts
(CAplus, REGISTRY)
Bibliographic information
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Summary
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Key values for users

• More data
• More explicit data than can be found via standard
  AI database search
• More comprehensive data than corresponding
  records in other products
• Integrated
• Mine a vast pool of scientific information
  sources via a single query
• Integrates Elsevier and MDL sources with other
  key information sources
• E.g. Derwent, ISI, Wiley, Springer
• Supports full-text linking with native (or any
  local OpenURL) link resolver
• Open
• NO USER LIMITS!
• Site licence model lets all researchers access at
  any time
• Easy to manage
• IP recognition, site-wide access

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A Better Way to Get Answers
Questions, Comments and Suggestions? Thank
you! Doreen Tan Product Sales Manager, Life
Science Elsevier ST (APAC) D.Tan_at_elsevier.com