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Transmission
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Prevention
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Testing
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Treatment
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Co-infection
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Love your Liver
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Prevention
Testing
Transmission
Treatment
Co-infection
Love your Liver
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11
Hepatitis C can be passed through blood, vaginal
secretions, saliva and breast milk. True or
false?

12
Name three risk factors for contracting the HCV
virus.
13
Sharing personal items such as a razor, nail
clippers, or toothbrush can spread HCV. True or
false?
14
How does HCV compare to HIV in terms of
how efficiently its transmitted from person to
person?
15
Is it possible to transmit the virus when you
have a chronic HCV infection?
16
Name three ways to prevent the transmission of
HIV.
17
Hepatitis C is primarily a sexually-transmitted
disease. True or false?
18
What is the difference between acute and
chronic Hepatitis C?
19
What is the correct way to clean your works if
you share injection equipment?
20
Everyone in North Carolina should know their HCV
antibody status.
21
A positive HCV ELISA test indicates that the
person has Hepatitis C.
22

• Which of the following
• is the way to determine if
• someone has the HCV virus?
• Hep C antibody test
• 2. PCR RNA test

23

• A liver biopsy checks for
• Levels of liver enzymes
• b. Type of HCV a person has
• c. The degree of liver damage
• d. Toxin level in the liver

24
As with HIV, the higher the HCV viral load, the
more sick the person is likely to be. True or
false?
25
Why is it important to know the genotype of your
patients HCV virus?
26
What are two possible goals of HCV therapy?
27
Does your team think that there is a cure for
Hepatitis C?
28
Name one of the two drugs that are used in the
treatment of Hepatitis C.
29
What are the side effects of interferon
treatment?
30
What care providers do you think should be on a
team when treating patients with Hepatitis C?
31
Current estimates show that ___ of North
Carolinians who are HIV are co-infected with
Hepatitis C.
32
Why is it important not to drink alcohol if you
have Hepatitis C - especially if you are HIV/
HCV coinfected?
33
How does co-infection with HIV affect
treatment for Hepatitis C?
34
When someone is coinfected, which disease is
likely to progress more quickly - HIV or Hep C?
35
What is now the leading cause of death for HIV/
Hep C coinfected persons?
36
Hepatitis C is the most common blood-borne virus
in the U.S. True or false?
37
Name the signs of acute Hepatitis C infection.
38
What are the basic functions of the liver?

39
Name the four stages of liver disease.
40
Is a healthy liver the size of a golf ball,
softball, football or basketball?

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Category
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Role of the liver
Makes proteins to build muscles Makes clotting
factor to stop bleeding Stores energy for later
use Makes bile for vitamin and nutrient
absorption
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Natural History of HCV Infection
Exposure (Acute phase)
15 (15)
85 (85)
HIV and Alcohol
Chronic
Resolved
80 (68)
20 (17)
Cirrhosis
Stable
75 (13)
25 (4)
HCC Transplant Death
Slowly Progressive
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Sources of Infection forPersons with Hepatitis C
Injecting drug use 60
Sexual 15
Transfusion 10 (before screening)
Other 5
Unknown 10
Nosocomial Health-care work Perinatal
Source Centers for Disease Control and Prevention
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Causes of death for HIV-HCV co-infected persons
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Increasing Mortality Due to ESLD in HIV-Infected
Patients
Pre-HAART Post-HAART
50
45
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Mortality Due to HCV-Related Disease ()
13
14
11.5
4.8
1.5
Brescia, Italy1 Boston, USA2 Madrid, Spain3
France4
1DiPerri G, et al. 8th CROI. Chicago, 2001.
Abstract 573. 2Bica I, et al. Clin Infect Dis.
200132492-497. 3Soriano V, et al. Eur J
Epidemiol. 1999151-4. 4Rosenthal E, et al.
AIDS. 2003171803-1809.
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HCV and Healthcare Workers
Risk of Transmission by Single Needle Stick to
Susceptible Healthcare Workers rule of
threes
40
30
30
Percent
20
10
3
0.3
0
HBV
HCV
HIV
Alter MJ N Engl J Med 1999341556 (NHANES III,
19881994).