Migraine

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Migraine
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Definition

• Migraine is more of neurological syndrome
  characterized by altered bodily perceptions,
  headache and nausea, that is more common in
  females than males.
• Few define it as a form of vascular headache
  caused by a combination of vasodilatation
  (enlargement of blood vessels) and the release of
  chemicals from nerve fibers that coil around the
  blood vessels.

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Pathophysiology

• Migraine has long been regarded as a vascular
  disorder because of the throbbing nature of the
  pain. However, vascular changes do not provide
  sufficient explanation of the pathophysiology of
  migraine. Up to one-third of patients do not have
  throbbing pain. Modern imaging has demonstrated
  that vascular changes are not linked to pain and
  diameter changes are not linked with treatment

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Vulnerability Genetic Basis

• Twin Studies MZgtDZ

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Comparison

• Psora
• Time
• Morning headache
• Location
• Frontal, Temporal, Tempo-parietal
• Character
• Headache is sharp, severe, paroxysmal
• Symptoms
• Headache with bilious attack of nausea and
  vomiting, red face and throbbing
• Modality
• Aggravation
• In morning
• Amelioration
• By rest, sleep, hot application

• SYPHILIS
• Time
• Night
• Location
• Usually Basilar, Linear, or one sided
• Character
• Dull, Heavy, Lancinating, Constant , Persistent
• Modality
• Aggravation
• At Night , Lying down, Warmth, Rest, While
  attempting to sleep
• Amelioration
• In morning, By Cold

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Comparison

• SYCOSIS
• Time
• Night or after midnight
• Location
• Frontal or on Vertex
• Character
• Headache of Sycotic children
• Produces Feverishness, Restlessness, Crying,
  Freting, and Worrying
• Concomitant
• Coldness of body, sadness and prostration
• Modality
• Aggravation
• By lying down, At Night, Riding, By exertion
  either physical or mental
• Amelioration
• By motion

• TUBERCULAR
• Time
• Headache occurring Weekly
• Character
• Headache is very severe and persistent
• Concomitant
• Coldness of hands and feet, sadness and general
  despondency
• Symptoms
• Patient has weak feeling about the head, can not
  hold it up, producing unconsciousness, rolling or
  boring of head into the pillow, feverishness, and
  restlessness, rush of blood to head or face, with
  roaring in ears
• Headache of children
• They strike, knock or pound their heads with
  their hands or against some object and great
  hunger before headache and headache from repelled
  eruption or suppression of any skin eruption
• Modality
• Aggravation
• By riding in carriage, preparing for examination,
  meeting with strangers and enertaining them
• Amelioration
• By rest, quiet, sleep, eating, and nose bleeding
• By cold application