MCB 407

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MCB 407 Metabotropic Receptors and Second
Messenger Signaling 10/2/07
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Fig 13-1
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Fig 13-11
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Fig 13-2
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Fig 13-4
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Classic GPCR Pathway GPCR AC- cAMP
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Fig 13-4
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Fig 13-5
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Negative Feedback Loops Phosphatases and
Phosphdiesterases.
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Fig 13-17
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Turning Off The Signal GRKs and Arrestins
GRKs G-protein receptor kinase turns DOWN
GPCRs (Bark beta andrenergic receptor kinase)
Arrestins Binds phosphorylated GPCRs turns
them off
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Short term vs. Long term Effects
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Fig 13-18
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In-Class Exercise

• What are the functional advantages of using an
  ionotropic receptor
• rather than a metabotropic one and vice versa.
• 2. Outline a signal transduction pathway that
  begins with the
• activation of a metabotropic 5HT receptor and
  leads to activation of
• a K mediated outward current.

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PLCb- IP3 and Calcium

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Negative Feedback?
IP3 broken down by inositol polyphsophate
phosphatase.
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Fig 13-7
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Crosstalk?
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Nicholls Figure 10.17
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Nitric Oxide Synthase
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Nicholls Figure 10. 15
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Summary Properties Of Signal Transduction
Pathways Amplification Adaptation
Desensitization Coincidence Detection Cross-
Talk Both Short-term and Long term
Effects Local Short Term Distant Long Term
Changes in Gene Expression