Enzogenol improves brain function A clinical trial

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Enzogenol improves brain function A clinical
trial
Enzogenol significantly improved cognitive
performance after only 5 weeks of supplementation
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ENZOGENOL
Enzogenol is a proanthocyanidin-rich polyphenol
extract from the bark of New Zealand grown Pinus
Radiata trees produced by ENZO Nutraceuticals Ltd
with patented pure water extraction technology
Dosage 100 - 1000 mg/day (depending on
condition severity)
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Brain Function Clinical Study

• Randomized, double blind, controlled study
• 42 male subjects
• Age 50-65 years
• 5 week supplementation, daily
• Treatment 960 mg of Enzogenol 120 mg vitamin
  C
• Control 120 mg vitamin C
• Baseline, 5 weeks
• Subjects sedentary occupation, do not exercise
  much, BMI gt 26, non-smokers

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Parameters measured

• 1. Computerized Cognitive Testing
• Testing performance of working memory using
  computer based tasks (response time and accuracy)
• Spatial Working Memory
  Task (SWM)
• Immediate Recognition
  Memory Task (IRM)

no no yes
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Enzogenol? improves brain performance
5 weeks of Enzogenol improved response times on
Spatial Working Memory (SWM) by 64 ms Immediate
Recognition Memory (IRM) by 60 ms (plt0.05). gt
Reducing brain age by 7- 12 years
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Parameters measured

• 2. Brain Electrical Activity Testing / Coherence
  Analyses
• Analyzing brain electrical activities and
  interaction
• of brain regions during working memory tasks
• Can Enzogenol improve brain region
  communication ?

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Brain Activityon Correct Trial Performance

• Comparing correct and incorrect trials shows
• Correct trial performance is strongly associated
  with long-range cortical decoupling (plt0.001)

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Enzogenol? improves brain communication
5 weeks of Enzogenol changed brain activity
patterns with a significant increase in
long-range cortical decoupling that is strongly
associated with correct decision making on these
cognitive tests.
gt Increased Brain Efficiency
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