Pharmacotherapy of Inflammatory Bowel Disease

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Pharmacotherapy of Inflammatory Bowel Disease

• Scott K. Stolte, Pharm.D.
• Curriculum Coordinator and
• Assistant Professor
• Division of Technology in Education

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Goals of Pharmacotherapy

• Improvement of disease symptoms
• Possible resolution of disease symptoms
• Prevention of acute attacks

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Goals of Pharmacotherapy, ctnd.

• Allow patients to carry on normal ADLs
• NO CURE!

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Medications

• Aminosalicylates Sulfasalazine and Mesalamine
  Derivatives
• Corticosteroids
• Short-Chain Fatty Acids (SCFAs)
• Immunosuppressants

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Medications, ctnd.

• Immune Modifiers Infliximab
• Nicotine
• Metronidazole

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Aminosalicylates

• First-line
• Most commonly prescribed

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Aminosalicylate Mechanism of Action

• Exact MOA unknown
• Prostaglandins
• Thromboxane
• Lipoxygenase

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Aminosalicylate Mechanism of Action, ctnd.

• Platelet Activating Factor (PAF)
• Antioxidant
• Interleukin-1
• Lymphocytes and Monocytes
• Plasma Cell Ig Production