IDeA Program: Structure and Impact

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IDeA Program Structure and Impact

• 4th Annual West Virginia COBRE/INBRE Conference
• October 26, 2008
• W. Fred Taylor, Ph.D.
• IDeA Program Director
• National Center for Research Resources
• National Institutes of Health
• U.S. Department of Health and Human
  Services

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Institutional Development Award ProgramDivision
of Research Infrastructure

• IDeA Program established in 1993.
• Authorized in NIH Revitalization Act of 1993
• Congressional intent to enhance geographical
  distribution of research funds and increase
  research capacity.
• Comparable to NSF Experimental Program to
  Stimulate Competitiveness in Research (EPSCoR),
  established in 1980.
• EPSCoR-like programs across 7 Federal Agencies
  (NIH, NSF, USDA, NASA, DOE, DOD, EPA).

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IDeA Program
INBRE 23 statewide networks COBRE 86 thematic
research centers
VT
ME
MT
ND
NH
ID
SD
RI
WY
NE
NV
DE
WV
KS
KY
OK
SC
AR
NM
MS
LA
AK
PR
HI
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Institutional Development Award ProgramDivision
of Research Infrastructure

• IDeA supports two specific programs
• Centers of Biomedical Research Excellence (COBRE)
  (FY 2008, 145 million) strengthen institutional
  biomedical research capacity by expanding and
  developing biomedical faculty research capability
  and enhancing research infrastructure. There are
  83 active COBRE centers.
• IDeA Networks of Biomedical Research Excellence
  (INBRE) (FY2008, 75 million) support networks of
  research and undergraduate institutions to
  enhance biomedical research capacity, expand and
  strengthen the research capabilities of
  biomedical faculty, and provides access to
  biomedical resources for promising undergraduate
  students. Currently, there is one INBRE in every
  IDeA state except New Hampshire.

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Centers of Biomedical Research Excellence (COBRE)
New (Type 1) Applications

• Purpose
• To build multidisciplinary research centers with
  a thematic scientific focus at doctoral
  institutions or research institutes
• Center Characteristics
• Led by an established investigator, funded by
  NIH, NSF or other comparable Federal or private
  sector source
• At least 3 research sub-projects, all supervised
  by junior investigators
• A clear plan for mentoring, career development
  and graduation and replacement of junior
  investigators
• Long-term plans for developing and sustaining the
  center, investigators, collaborations, and
  physical infrastructure

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Centers of Biomedical Research Excellence (COBRE)
Competing Continuation (Type 2) Applications

• Purpose
• To obtain continuation funding to build an
  independent multidisciplinary research center
  that can compete successfully for NIH funding
  from other sources
• Center Characteristics
• Comprising 3 to 5 research sub-projects
• Each sub-project supervised by a qualified
  investigator (eligibility expanded relative to
  type 1 COBRE)

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IDeA Networks of Biomedical Research Excellence

• INBRE Goals
• Develop a statewide multi-disciplinary research
  network of doctoral degree granting and
  undergraduate institutions
• Build and increase the research capacity by
  supporting faculty, fellows and students at
  participating institutions
• Provide undergraduate faculty and students
  research support, serve as pipeline to health
  research careers
• Provide outreach to students at undergraduate
  institutions, community and tribal colleges and
  K-12
• Enhance statewide science and technology
  knowledge base

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Institutional Development Award ProgramDivision
of Research Infrastructure
- FY06 FY07 exclude RD contract funding
(data unavailable)
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Institutional Development Award ProgramDivision
of Research Infrastructure

• IDeANet to Enhance Network Connectivity at
  Developing Institutions
• All participants in the IDeA Program (present and
  future) and participants in NCRRs Research
  Centers in Minority Institutions (RCMI) Program
• Connections to other NIH-supported research
  networks
• Connections to researchers and educators across
  the country and around the world
• Funding to enhance IT infrastructure for health
  research and dissemination
• (http//www.ncrr.nih.gov/resinfra/ri_idap.aspIDeA
  Net)

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Institutional Development Award ProgramDivision
of Research Infrastructure

• Examples of IDeANet
• Lariat
• Louisiana Optical Network Initiative
• Northeast Network Initiative
• IDeA Bioinformatics/Cyberinfrastructure cores in
  each INBRE Statewide Network

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Institutional Development Award ProgramDivision
of Research Infrastructure

• Community-Based Research Infrastructure
• Facilitate community-based clinical and
  translational research addressing health
  disparities in under-served populations
• Support development of sustainable, culturally
  appropriate prevention/intervention research
  programs to decrease the disproportionate burden
  of disease
• Promote interdisciplinary, multi-site
  collaborations between academic researchers and
  community health care providers
• Develop effective and stimulating environments to
  facilitate training and development of clinical
  investigators in areas of health disparities and
  special populations

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Examples of IDeA-funded community-based clinical
and translational research

• Cultural Understanding of Health - Obesity and
  Cardiovascular Disease (U. Alaska, Fairbanks
  COBRE)
• Appalachian Cardiovascular Research Network
• (West Virginia INBRE)
• Epidemiology of Oral Disease and Diabetes
• (Medical U. of South Carolina COBRE)
• Community Health and Health Outcomes in Rural
  Populations (Wyoming INBRE)
• Low back pain and depression (Arkansas COBRE)

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Institutional Development Award ProgramDivision
of Research Infrastructure

• IDeA Sponsored Activities in West Virginia
• INBRE
• P20RR016477 Dr. Gary Rankin
• COBRE
• P20RR015574 Dr. George Spirou
• P20RR016440 Dr. Dan Flynn
• P20RR020180 Dr. Richard Niles

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Institutional Development Award ProgramDivision
of Research Infrastructure

• INBRE
• P20RR016477 Dr. Gary Rankin
• Statewide network of 14 institutions
• Promotes interactions and collaboration of
  biomedical scientists and students across all
  institutions
• Creates jobs and provides career opportunities
  for students
• Promotes the attraction and retention of
  biomedical faculty and students
• Supports biomedical research and research cores
• Genomic and proteomic technology
• Flow Cytometry laboratory
• Proteomics Core

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Institutional Development Award ProgramDivision
of Research Infrastructure

• INBRE
• P20RR016477 Dr. Gary Rankin
• Community based research program (ACoRN)
• Improved detection and diagnosis of
  Cardiovascular disease
• Identification of genomic markers for Familial
  Combined Hypertension
• Bioinformatics infrastructure and training
• Bioinformatics core and tools
• Training for more than 130 faculty and students

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Institutional Development Award ProgramDivision
of Research Infrastructure

• COBRE
• P20RR015574 Dr. George Spirou
• Sensory Neuroscience Center
• One of four sensory neuroscience centers in the
  United States
• New faculty and other personnel
• 6 new faculty, 12 postdoctoral fellows, 22
  graduate students and 19 technicians
• Core Facilities
• Confocal microscope, live cell imaging systems,
  histology, biochemistry, molecular biology
• Transgenic Rodent Core, Electron Microscopy,
  Affymetrix System, Non-linear Optical imaging
• Computational Biology

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Institutional Development Award ProgramDivision
of Research Infrastructure

• COBRE
• P20RR015574 Dr. George Spirou
• Health Benefits
• New gene candidates for glaucoma in humans
• Identified new central nervous system components
  in asymmetric hemispheric processing of visual
  information
• Expansion of cortex devoted to categorical
  processing of sound documented in blind humans
• New animal models created to study malformation
  of the eye and retinal degeneration
• Impact on Education
• Summer Undergraduate Research Program
• Junior faculty mentoring accelerating faculty
  development and increased number of pre- and
  postgraduate trainees
• Center faculty integral to a training grant in
  Biomedical and Behavioral Neuroscience

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Institutional Development Award ProgramDivision
of Research Infrastructure

• COBRE
• P20RR016440 Dr. Dan Flynn
• New faculty and other personnel
• 9 new faculty, 16 COBRE faculty, 10 postdoctoral
  fellows, 28 graduate students and 7 technicians
• Core Facilities
• Imaging and Microscopy cores
• Proteomics, Flow Cytometry and Molecular Modeling
• Pharmacodynamics and Pharmacokinetics

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Institutional Development Award ProgramDivision
of Research Infrastructure

• COBRE
• P20RR016440 Dr. Dan Flynn
• Health Benefits
• Clinical trials program focused on cancer health
  disparities in West Virginia
• Technology Development
• Protea Biosciences, Inc.
• Protea Euro, Nimes, France
• 2 device patents (cancer nanotechnology devices)
• 3 biological/chemical patents (biomarkers)

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Institutional Development Award ProgramDivision
of Research Infrastructure

• COBRE
• P20RR020180 Dr. Richard Niles
• New faculty and other personnel
• Recruitment of 3 new junior and 2 senior faculty
  into basic science departments
• The Center has contributed to 13 Ph.D. students
  thesis research in the Cancer Biology Center
• Contributed to the recruitment of new oncology
  clinical faculty members and to translational
  research and a clinical trial ongoing in the
  Center
• New faculty facilitated the development of the
  Nutrition and Cancer Center (new thematic focus)

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Institutional Development Award ProgramDivision
of Research Infrastructure

• COBRE
• P20RR020180 Dr. Richard Niles
• Health Benefits
• Identified a tumor suppressor gene in human
  pancreatic cancer
• Demonstrated the inhibition of cytotoxic activity
  of a chemotherapeutic agent in human
  neuroblastoma cells
• Technology Development
• Phoenix Biotherapeutics started by COBRE faculty
  member

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Institutional Development Award ProgramDivision
of Research Infrastructure
Opportunities for Inclusion