Individual Food Choices Affect

1
Individual Food Choices Affect Tissue
Essential Fatty Acids and
Eicosanoid Response Intensity
http//ods.od.nih.gov/eicosanoids
http//www.nagoya-cu.ac.jp/eicosanoids
2
short6 182n-6 PUFA short3 183n-3
PUFA long6 203204224n-6 HUFA long3
205225226n-3 HUFA
3
Dietary Lipids
Plasma Lipoproteins
Triglycerides
Membrane Phospholipids
Lipoprotein Lipase
Diglycerides
Elongation Desaturation
HUFA
NEFA
Phospholipase
(n-3) (n-6) 18C 18C PUFA 20C 20C HUFA 22C
22C HUFA
NEFA
Acyl-CoA
Lipoprotein Remnants
Endothelium
Eicosanoids
Plasma NEFA
CO2 H2O
Inflammatory Oxidant Stress
LPS
Tissue Lipase
Adipose Tissue Fat
4
(No Transcript)
5
Disorders with Excessive Omega-6
Eicosanoid Actions
Heart Attack Thrombotic Stroke Arthritis
Asthma Colitis Headaches
Inflammation Menstrual Cramps Metastases
Osteoporosis
6
(No Transcript)
7
(No Transcript)
8
Four Types of Dietary Essential Fatty Acids
18-carbon omega-6 182n-6
18-carbon omega-3 183n-3
20-22-carbon omega-6 203, 204, 224n-6
20-22-carbon omega-3 205, 225,
226n-3 Predictably maintain the proportion of
omega-6 in 20- 22-carbon acids (HUFA) of
tissues - - as a
useful surrogate clinical marker. Lands, Am.
J. Clin. Nutr. 1995 61(suppl) 721S-725S.
9
(No Transcript)
10
(No Transcript)
11
(No Transcript)
12
Individual Food Choices Affect Tissue
Essential Fatty Acids and
Eicosanoid Response Intensity
http//ods.od.nih.gov/eicosanoids
http//www.nagoya-cu.ac.jp/eicosanoids
13
Conditions for which you take aspirin,
ibuprofen(Motrin), acetominophen(Tylenol), COX-2
blockers, NSAIDs all have excessive
6-eicosanoids
14
HC31.5 HC61.1 PC30.0555
PC60.441 HI30.004 HI60.040
Co5.0 Ks0.175