AlphasuccinylLHomoserine

1
A
L-Homoserine
AcetlyCoA
SuccinylSCoA
2.3.1.31
2.3.1.46
CoA
HSCoA
Alpha-succinyl-L-Homoserine
L-Cysteine
E.coli
S.cerevisiae
O-acetyl-homoserine
4.2.99.9
Succinate
Cystathionine
H2O
Sulfide
4.4.1.8
4.2.99.10
NH4
Pyruvate
Homocysteine
5-MethylTHF
2.1.1.14
THF
L-Methionine
van Helden et al., Figure 1A
2
B
L-Homoserine
AcetlyCoA
SuccinylSCoA
2.3.1.46
2.3.1.46
2.3.1.46
2.3.1.46
CoA
HSCoA
Alpha-succinyl-L-Homoserine
4.2.99.9
L-Cysteine
O-acetyl-homoserine
4.2.99.9
4.2.99.9
Succinate
4.2.99.9
Cystathionine
H2O
Sulfide
NH4
Pyruvate
Homocysteine
5-MethylTHF
THF
L-Methionine
van Helden et al., Figure 1B
3
C
2.3.1.31
2.3.1.46
Alpha-succinyl-L-Homoserine
4.2.99.9
O-acetyl-homoserine
Cystathionine
4.4.1.8
4.2.99.10
Homocysteine
Homocysteine
2.1.1.14
van Helden et al., Figure 1C
4
D
L-Homoserine
AcetlyCoA
SuccinylSCoA
2.3.1.31
2.3.1.46
CoA
HSCoA
Alpha-succinyl-L-Homoserine
L-Cysteine
O-acetyl-homoserine
4.2.99.9
Succinate
Cystathionine
H2O
Sulfide
4.4.1.8
4.2.99.10
NH4
Pyruvate
Homocysteine
5-MethylTHF
2.1.1.14
THF
L-Methionine
van Helden et al., Figure 1D
5
A
Reactions
dihydrodipicolinic acid
L-Aspartic Semialdehyde
4.2.1.52
H2O
Pyruvate
succinate
Sucinyl diaminopimelate
3.5.1.18
LL-diaminopimelic acid
H2O
Invalid path
L-Aspartic Semialdehyde
LL-diaminopimelic acid
4.2.1.52
H2O
3.5.1.18
van Helden et al., Figure 2A
6
B
Reaction
dihydrodipicolinic acid
L-Aspartic Semialdehyde
4.2.1.52
H2O
Pyruvate
Valid path
4.2.1.52
dihydrodipicolinic acid
L-Aspartic Semialdehyde
Invalid path
L-Aspartic Semialdehyde
4.2.1.52
Pyruvate
van Helden et al., Figure 2B
7
C
Reactions
dihydrodipicolinic acid
L-Aspartic Semialdehyde
4.2.1.52
H2O
Pyruvate
dihydrodipicolinic acid
L-Aspartic Semialdehyde
4.2.1.52 reverse
H2O
Pyruvate
Invalid path
4.2.1.52 reverse
dihydrodipicolinic acid
L-Aspartic Semialdehyde
4.2.1.52
Pyruvate
van Helden et al., Figure 2C
8
A
C
B
van Helden et al., Figure 3
9
A
Aspartate biosynthesis
L-Aspartate
ATP
aspartate kinase III
lysC
2.7.2.4
ADP
L-aspartyl-4-P
NADPH H
aspartate semialdehyde deshydrogenase
asd
Methionine biosynthesis
1.2.1.11
NADP Pi
L-aspartic semialdehyde
Threnonine biosynthesis
pyruvate
dihydrodipicolinate synthase
dapA
4.2.1.52
2 H2O
dihydropicolinic acid
NADPH or NADH H
dihydrodipicolinate reductase
dapB
1.3.1.26
NADP or NAD
tetrahydrodipicolinate
succinyl CoA
tetrahydrodipicolinae N-succinyltransferase
dapD
2.3.1.117
CoA
N-succinyl-epsilon-keto-L-alpha-aminopimelic acid
glutamate
succinyl diaminopimelateaminotransferase
dapC
2.6.1.17
alpha-ketoglutarate
succinyl diaminopimelate
H2O
N-succinyldiaminopimelatedesuccinylase
dapE
3.5.1.18
succinate
LL-diaminopimelic acid
diaminopimelateepimerase
dapF
5.1.1.7
meso-diaminopimelic acid
lysRprotein
diaminopimelatedecarboxylase
lysR
lysA
3.5.1.18
CO2
L-lysine
van Helden et al., Figure 4A
10
A
B
van Helden et al., Figure 5