Glycolysis Part 2 Regulation'

1
Glycolysis Part 2 Regulation.
2

• Points of regulation.
• Transport into the cell insulin.
• Hexokinase
• Phosphofructokinase
• Pyruvate kinase

3
(No Transcript)
4
1. Insulin and glucose transport.
Only in muscle adipose tissue
5
2. Hexokinase fates of glucose-6-P
Liver
6
In most tissues, hexokinase is inhibited by
glucose-6-P. The purpose is to control
glycolysis.
7
The liver is different. (1) Controls responds
to blood glucose conc. (2) It synthesizes
glyogen breaks it down when needed.
Glucokinase (1) has high Km still
active at high glucose concentration
synthesizes glycogen. (2) not inhibited by
glucose-6-P.

8
3. PFK-1 A. ATP and AMP B. pH C. Fructose-2,6-b
isphosphate
9
(No Transcript)
10
activates PFK-1.
11
Hormone effects. Insulin decrease blood
sugar Epinepherine increase blood
sugar Glucagon increase blood sugar
12
Glucagon through phosphorylation of PFK-2 and
the phosphatase regulates the fructose-2,6-bisph
osphate
Which in turn regulates FPK-1.
13
4. Pyruvate kinase
14
(No Transcript)