Conducting Stem Cell Research: Special Requirements and Application Procedures

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Conducting Stem Cell Research Special
Requirements and Application Procedures

• Isolde Bates, Administrative Director
• UConn Stem Cell Institute
• D. C. Saha, PhD, Director, ORSP
• Office of Research Administration and Finance

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• Proposals
• Established Investigator 500,000
• (including indirect cost) for up to 4 years.
• Group Project 2Mil
• (including indirect costs) for up to 4 years.
• Core Grants 2.5Mil
• (including indirect costs) for up to 4 years.
• Seed Grants 200,000
• (including indirect cost) for 2 years.

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Common AbbreviationsESCRO Embryonic Stem Cell
Research OversighthESC Human Embryonic Stem
CellWebsite for Applicationhttp//www.dph.state
.ct.us/StemCell/Grants.htmESCRO
Websitehttp//www.escro.uconn.edu/Anne L.
HiskesChair, ESCRO Committeeanne.hiskes_at_uconn.ed
u
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Attachment I Cover Page
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Attachment II Project Summary
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• 4. Project Description
• c. Intellectual Property
• The following statement was provided by the
  Center for Science and Technology
  Commercialization (CSTC)
• Per University of Connecticut policy, any
  invention, whether patentable or not, developed
  during the course of this project will be
  disclosed to the Universitys Center for Science
  and Technology Commercialization, which handles
  patenting and licensing for the University.

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5. Evidence of Commitment

• a. Commitment of Institution, Hospital or Company
  and other Collaborators
• See attached Institutional Letter of Commitment
  from President Hogan.
• Dr. Lalande will provide a letter signed by
  President Hogan to be submitted with the
  proposal. Depending on when available we will
  email. The letter will also be available on the
  ORSP website to be included during routing and
  will be posted on the ESCRO website.

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• Examples
• c. Commitment to Sharing Resources
• Protocols, reagents and significant findings will
  be shared with the State of Connecticut Stem Cell
  Research Community.
• d. Financial Commitment from other Sources
• The requested budget is sufficient for the
  proposed outlined experiments.

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Attachment III Budget Use Fringe Rates as
listed on ORSP website
State Retirement 63 Alternate Retirement
with FICA and Medicare 40 Alternate Retirement
with Medicare, no FICA 33 Alternate Retirement
w/o FICA or Medicare 32 Graduate
Assistants/Foreign Nationals 19.40
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Budget Justification (Example)

• Personnel . total funds of .... for project
  period will be used to cover the salaries and
  fringe of PI and ??? as listed.
• Equipment 2,000 requested in year 1 for the
  purchase of a computer. The computer is needed
  to..
• Materials and Supplies total for both years
  will cover
• itemize by category such as chemicals, reagents,
  disposables, etc.
• Other include items such as animal care,
  repair/maintenance, facs, etc.
• All budget items must be itemized with
  breakdown and explanation.
• Above costs were estimated based on current
  market pricing to achieve the milestones as
  described in the research plan.

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• Proposal Format
• Stapled in upper left hand corner but otherwise
  unbound
• Pages numbered at the bottom.
• Font 12 point
• Margins one inch

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Proposal Routing

• Stem Cell Proposals require two routing forms.
• The first routing form is the standard ORSP form
  used for all grants. For the start date we will
  use June 1, 2008. This is an estimated date.
  Proposals will not get awarded until all
  approvals are in place and DPH receives final
  word from Anne Hiskes.

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• The second routing form is the Supplemental
  Routing Form for Proposals Involving the Use or
  Creation of Human Stem Cells.
• Supplemental Routing Form
• This form must accompany all the stem cell
  applications.
• Both Routing Forms can be downloaded from the
  ORSP website.
• http//resadm.uchc.edu/orsp/index.html

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• ORSP recommends to start the
• routing process the week of
• October 22, 2007.

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SubmissionDue DateThursday, November 1,
2007430PMOne hard copy delivered to
Connecticut Stem Cell Research Grants
ProgramConnecticut Innovations200 Corporate
Place, 3rd FloorRocky Hill, CT 06067860 563-5851
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• One electronic proposal in PDF format emailed
  tostemcellinfo_at_ctinnovations.com
• Hard copy and electronic version must match

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• For the submission of the application ESCRO, IRB,
  ACC, IBC approvals are not needed and can be
  listed as pending.

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• CONTACT NAME FOR ADDITIONAL
• QUESTIONS IN REGARDS TO THE APPLICATION
• Pamela Hartley
• Connecticut Innovations
• Direct phone [phone]
• E-mail pamela.hartley_at_ctinnovations.com

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• Seed Grants/Postdoctoral Fellows
• Proposal must include a Letter of Support and
  Biosketch from the Faculty Sponsor(s). The
  sponsors letter must address the following
• The post-doc's faculty mentor agrees in
  writing to commit the resources necessary for the
  project
• The post-doc's mentor agrees to assume full
  responsibility for completion of the project, or
  for it's orderly close-out/termination, including
  (but not limited to) responsibility for all
  reporting requirements removal of
  hazardous/controlled substances that the post-doc
  may have left behind arranging for euthanasia of
  animals left behind
• The mentor agrees to assume responsibility
  for serving as PI on IRB/ACC applications, and
  the responsibilities associated with such status,
  e.g., reports, follow-up, etc.