Title: MAXIMIZING THE UTILITY OF THE PRIME ECG
1MAXIMIZING THE UTILITY OF THE PRIME ECG
- James Hoekstra, MD
- Professor and Chairman
- Department of Emergency Medicine
- Wake Forest University
2SO HOW DO YOU READ THIS DAMN THING ANYWAY??
- Patient Selection
- Evaluating the PRIME ECG results
3PRIME ECG Patient Selection
- The PRIME ECG does not replace the screening ECG
- Too time intensive
- Too expensive
- PRIME sensitivity and specificity was determined
from high risk subsets of patients - Low risk chest pain patients will result in high
false positive rates, just like the 12 lead ECG
4PRIME ECG Patient Selection
- High Risk Patients
- High index of suspicion for evolving STEMI
Serial PRIME - ST Depression
- Abnormal but nonspecific ECG, BBB, LVH
- Troponin Positive (after TnI or TnT comes back)
- TIMI 2
5PRIME ECG Patient Selection
- Should not be used to screen for safe to go
home screening scenarios - Should not be used in observation unit patients
(TIMI 0-1) - Should be used in admissions, in serial
fashion, especially if high risk
6Reading the PRIME ECG
- Regimented Reading
- Assure a quality recording
- Stepwise approach to reading
- Match the ECG to the Patient
- Like the 12 Lead ECG, when in doubt, go back to
the clinical scenario
7Reading the PRIME ECG
- Regimented Reading Approach
- Low Quality Screen
- Assisted Beat Markings
- 80 Lead Screen
- 4 MAP View
- STO Filter View
- Computerized Reading
8PRIME ECG Case Study54 yo Male with Chest Pain
-
- Arrives in the ED with chest pain that had been
constant since 11 AM. - Pain is described as intense, midline substernal,
radiating to the left arm, associated with
shortness of breath and nausea. It began with
light walking. It feels like his prior MI pain - Pain 8/10 on arrival, in mild distress
954 year old Male with CP (PMH)
- PMH CAD, MI
- Prior stent placed for MI
- SH Smoker
- FH Noncontributory
- Meds ASA. Noncompliant with other medications
1054 year old Male with Chest Pain (ECG)
- Normal Sinus Rhythm at 72 bpm
- ST depression anteriorly
- Tall R waves anteriorly
1154 year old Male with CP (Ancillary)
- Chest Xray Normal
- Initial Cardiac Markers
- CK 37, MB ,1.0
- TnI lt 0.05
- Renal Function Normal
- Hb 14
- TIMI 5
12PRIME ECG Applied
1354 year old Male with CP (PRIME)
Low Qual
- STEP 1 LOW QUALITY REVIEW
1454 year old Male with CP (PRIME)
Rate, Axis, Intervals
80 Lead Toggle
Low Quality Lead
- STEP 1 LOW QUALITY REVIEW
1554 year old Male with CP (PRIME)
Hit Analyze Button
If OK, Accept
- STEP 2 ACCEPT BEAT MARKINGS
1654 year old Male with CP (PRIME)
STO Takeoff
End of T
Start of QRS
- STEP 2 ACCEPT BEAT MARKINGS
1754 year old Male with CP (PRIME)
80 Lead View Button
- Step 3 Scroll Through the 80 Leads
1854 year old Male with CP (PRIME)
4 View
Torso View
Isolate PQRST
Max ST Deviation
- Step 4 MAP 4 View (Torso)
1954 year old Male with CP (PRIME)
STO
2054 year old Male with CP (PRIME)
Rotate
2154 year old Male with CP (PRIME)
- Step 6 Read the Analysis Post MI
2254 year old Male with CP (ED Course)
- Cardiology consulted for possible acute posterior
MI - Cardiologist saw pt in the ER
- Pain reduced, workup complete, decision is made
to admit to CCU for medical management pre-cath
(treat as NSTE ACS)
2354 year old Male with CP (CCU Course)
- Second set of markers elevated with CKMB 37, TnI
6.6 - Pain continues, 2-3/10, despite maximal medical
management - Patient taken to cath lab for urgent PCI
24 54 year old Male with CP (Cath Results)
- 99 thrombotic lesion of the proximal first
obtuse marginal off the circumflex - Remainder of circumflex without stenoses
- LAD and RCA with mild lumenal irregularities,
none more than 20 obstructive - LVEF 50
25 54 year old Male with CP (Course)
- Patient underwent PCI with taxus stent of the
proximal obtuse marginal 99 lesion with good
result. - Discharged home on hospital day 5
- Final diagnosis Acute Posterior MI
26PRIME ECG Case Study53 yo Male with Chest Pain
-
- Arrives in the ED with chest pain that had been
stuttering for the past 12 hours - Pain is described as dull, substernal, associated
with shortness of breath and nausea - Pain 2/10 on arrival, in no distress
2753 year old Male with CP (PMH)
- PMH HTN, CVA, Seizures, CAD, Ashma
- EF 40 secondary to past MIs (anatomy unclear due
to cath at outside hospital) - SH Smoker 1 ppd X 30 years
- FH Noncontributory
- Meds ASA, Lipitor, Lisinopril, Lamictal,
Albuterol, Lopressor, Neurontin
2853 year old Male with Chest Pain (ECG)
- Normal Sinus Rhythm at 79 bpm
- Diffuse nonspecific ST/T wave changes
anteriorly - Early R wave progression anteriorly
2953 year old Male with CP (Ancillary)
- Chest Xray Mild cardiomegaly, no CHF
- Initial Cardiac Markers
- CK 221, MB 5.3
- TnI lt 0.05
- Renal Function Normal
- Hb 14
30Pain ReturnsPRIME Obtained
3153 year old Male with CP (ED Course)
- Cardiology consulted for acute anterior MI
- Cath Lab Activated
- Cardiologist at Bedside, agrees with PRIME
interpretation - Angiogram performed
3253 year old Male with CP (Cath Results)
- LAD with 95 mid lesion
- Critical stenosis of first diagonal branch
- 85 circumflex 2nd OM lesion
- 70 circumflex 3rd OM lesion
- 75 lesion of PDA off the RCA
- Apical hypokinesis and LVEF 40
33 53 year old Male with CP (Course)
- Cardiothoracic Surgery consulted for CABG due to
triple vessel disease - Felt not to be surgical candidate due to prior
CVA - Day 2 underwent stenting of LAD 95 lesion,
without complication - Peak Troponin 0.10
- Discharged home on hospital day 5
- Diagnosis Unstable Angina
34PRIME ECG Case Study62 yo Male with Chest Pain
-
- Arrives in the ED by EMS with chest pain that has
been intermittent for 2 days, and constant for
the last 2 hours. - Pain is described as substernal, radiating to the
left arm, associated with shortness of breath and
nausea. He has been taking NTG without relief - Pain 8/10 on arrival, in moderate distress
3562 year old Male with CP (PMH)
- PMH CAD, MI, DM, HTN, CHF, Neuropathy
- PSH CABG, Pacemaker
- SH Nonsmoker
- FH MI
- Meds ASA, Clopidogrel, Glucophage, Lantis,
Lopressor, Lisinipril, Lasix, Lipitor, Neurontin
3662 year old Male with Chest Pain (ECG)
- Normal Sinus Rhythm at 72 bpm
- Bifascicular Block RBBB and LAHB
- Diffuse ST depression over anterior leads
37PRIME Obtained
3862 year old Male with CP (ED Course)
- Cardiology consulted for possible acute posterior
MI - Cardiologist at bedside. Agrees with PRIME
Reading - Patient offered PCI, but initially not willing to
undergo cath. Agreed later after second set of
TnI elevated at 6.1
39 62 year old Male with CP (Cath Results)
- LAD, RCA, and circumflex all occluded from the
native circulation. - LIMA graft to LAD patent, distal LAD 80 stenosis
- Saphenous graft to the RCA patent without
stenoses - Saphenous graft to the circumflex occluded at the
distal anastomosis - LVEF 30
40 62 year old Male with CP (Course)
- Patient underwent PCI with taxus stent of the
distal saphenous graft to the circumflex, with
good results. - Patient admitted to the CCU post procedure
- Peak CKMB gt80, Peak TnI gt30
- Discharged home on hospital day 5
- Final diagnosis Acute Posterior MI
41OCCULT MI TRIAL
- Mitchell Krucoff, MD and James Hoekstra, MD -
Co-chair - Heartscape - Sponsor
- Steering Committee
- DCRI - Prime ECG Core Laboratory
- PERFUSE Angiographic Core Lab
- Cardiovascular Clinical Studies -CRO
42OCCULT MI Trial Sites
Bay State Medical Center
Occult-MI study 1400 patients 10 sites
Columbia-Presbyterian
William Beaumont
Thomas Jefferson
Cleveland Clinic
Wake-Forest
UC-Davis
University of Cincinnati
Duke
Medical University of South Carolina
Tallahassee Heart Vascular Institute
Tampa General
43Inclusion Criteria
- Able to consent
- gt39 years old
- Has access to a working telephone and the ability
to hear by phone - Non-trauma associated ACS symptoms beginning 12
hours or less before presentation - Chest pain and at least one of the following (i)
ECG abnormality (ii) known CAD (iii) at least 3
coronary risk factors for CAD (including family
history, current or treated hypertension,
hypercholesterolemia or treatment for it,
diabetes mellitus and/or subject is a current
smoker).
44Exclusion Criteria
- Symptoms gt 12 hours
- Prior 12-lead STEMI within the past 48 hours
- Hemodynamic instability
- Cardiogenic shock
- Pulmonary edema (Killips class 3 overt failure
with 1/3 of lung fields) - Recent trauma.
45Methods Data Capture
- Prospective, cohort study of PRIME ECG
- Participants blinded to PRIME result
- Brief medical history (vital signs, height,
weight, cardiopulmonary exam, concomitant
medications) - 12-L and PRIME SERIAL recordings near
simultaneous at enrollment, simultaneous at
change of symptoms or at least one additional
recording within 3 hours with pain assessment at
time of each recording - Clinical labs including cardiac markers must
include troponin I or T - TIMI risk assessment
- Interventional therapies
- Angiographic films
- Results of stress MPI, echocardiography, and
SPECT scan during index ED visit /
hospitalization - 30 day f/u for MACE
46Primary Endpoint
- DTST for Prime-only STEMI subjects vs. STEMI
subjects. - DTST will be measured in minutes, from the time
stamped on the ED intake sheet to the time of
sheath insertion in the cardiac catheterization
laboratory.
47Secondary Endpoints
- 10 endpoints of clinical and economic factors
- Sub-group analyses between Prime-only STEMI,
STEMI, non-STEMI - Clinical factors analyzed will include 30-day
MACE rates, AMI detection, ACS detection,
angiographic determination of arterial
stenosis/occlusion, revascularization rates,
medical therapy regimens
48PRIME ECG Case OCCULT MI
- 6/10 Pain
- ECG with ST depression only in anterior and
lateral leads - Posterior leads OK
- PRIME ECG applied
001-046
49PRIME ECG Case Resolution
- Door to cath time 486 minutes
- TnI 186X ULN
- Final Dx NSTEMI
50PRIME ECG Case OCCULT MI
- ECG with nonspecific findings
- TIMI 2
- Pain 2/10 on arrival, PRIME Applied
003-0148
51PRIME ECG Case Resolution
- PRIME reading lateral ischemia
- No cath
- Troponin 210X ULN
- Final Dx NSTEMI
52PRIME ECG Case OCCULT MI
- Pain 2/10 on arrival
- ECG shows lateral ST depression
- PRIME Applied
- Serial Studies done 30 minutes apart as pain
continued
004-0124 (2)
53PRIME ECG Case Resolution
- Rx as Unstable Angina
- Cath at 6022 min
- TnI 11X ULN
- Dx NSTEMI
54QUESTIONS??