Hand in Lecture Problem 6 Go over solution

1
Lecture 17

• Hand in Lecture Problem 6 Go over solution
• Ch 9 Synthetics/Reactions
• This week in lab
• Ch 6 Final Report Due
• Synthetic Selection Sheet Due (Ch 9)
• Procedure 2 of Ch 8
• Next week in lab
• Synthetic Experiment 1 PreLab Due

2
Synthetic Experiment Selection Sheet

• Due this week
• Select 5 of the 50 experiments listed on page
  201 in the
• Lab Guide do not choose experiments that are
• similar reaction types or that have the same
  types of
• analyses
• Do NOT pick 70, 114, or 204!!
• Fill out the sheet completely
• Tear out the sheet and turn it in at the
  beginning
• of the lab period
• Your TA will tell you the 2 of the 5 that you
  will do

3
Ch 9 Synthetics

• Main types of reactions
• Oxidation and reduction
• Esterification
• Friedel-Crafts
• Elimination
• Substitution
• Aldol reaction
• Aldol condensation

4
Ch 9 Synthetics

• Read chapter 9 thoroughly (Quiz 6)
• Download revised PreLab grade sheets from website

• Info in Chapter 9
• Comments on Synthetic Experiments
• Instrument Room Comments
• Miscellaneous Comments Techniques
• Troubleshooting

5
Comments on Synthetics

• May need to repeat an experiment.
• Yields count! The quality of your technique
  will be
• evaluated.
• Check Chemical Inventory when looking for
  chemicals check
• hooded shelf, common shelf, refrigerators, ask
  class/TA,
• or ask stockroom
• Get melting points for all solid products.
  Report yields for
• all products.

6
Instrument Room Comments

• Make up samples for spectral analysis during
  your lab time!
• If you need to run a GC-MS, you must run a GC
  first!
• RI is refractive index. It is a physical
  property just like
• boiling point for liquid samples.
• Please do not leave samples in the Instrument
  Room. During
• your lab time, collect your samples from the
  Instrument Room
• and keep them in your locker. At the end of
  the semester,
• dispose of your samples.

7
Miscellaneous Comments Techniques

• Chemicals may be stored in dessicator jars. You
  will also see
• DrieRite in these jars. It is a drying agent
  (blue and white
• chips). Do not mistaken DrieRite for your
  chemical.
• Anhydrous solvents are stored in septum-topped
  bottles.
• Inserting tubing through a septum.
• Sealing capillary tubes
• Weighing liquids
• Syringe-pipet connections
• Instant micro scale distillation

8
Troubleshooting

• No product formed
• No reaction - recovered starting material
  verify by TLC
• Check reagent bottles
• Check times and temperatures
• Check calculations
• Low yield after recrystallization
• Added too much solvent? Concentrate solution.
• Obtain an oily-non-crystalline product? Try to
  recrystallize
• product to get a solid.