A randomised comparative study of patients tolerance of and adherence to Combivir and tenofovir vers

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A randomised comparative study of patients
tolerance of and adherence to Combivir and
tenofovir versus stavudine and tenofovir as HIV
post-exposure prophylaxis (PEP)

• Hawkins D, Higgs C, Mandalia S, Nwokolo N
• Directorate of Sexual Health and HIV,
• Chelsea and Westminster Hospital, 369 Fulham Road
• London, SW10 9NH, UK

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(No Transcript)
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Clinical adverse events
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Discussion

• Small study difficulties with real time
  recruitment
• No difference in adherence under study conditions
• Confirms poorer tolerability of AZT containing
  regimen (as in historical control studies)
• Now suitable alternatives time to move on?

Winston A et al. The use of a triple
nucleoside-nucleotide regimen for non-
occupational HIV post-exposure prophylaxis. HIV
Med 200561917 Mayer K,et al. Tenofovir/3TC
for non-occupational post-exposure prophylaxis
improved 2005. Rio de Janeiro, Brazil (abstr.
WePe10.3P08)