Ranolazine: Pathophysiologic effects vs older antianginals

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Ranolazine Pathophysiologic effects vs older
antianginals
O2 Demand
O2 Supply
Myocardial contractility
Venous return
Arterial pressure
Heart rate
Coronary blood flow
Drug class
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ß-blockers
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DHP CCBs
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Non-DHP CCBs

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Long-acting nitrates





Late Na current inhibitors(ranolazine)
Boden WE et al. Clin Cardiol. 20012473-9.
Gibbons RJ et al. ACC/AHA 2002 guidelines.
www.acc.org/clinical/guidelines/stable/stable.pdf
Kerins DM et al. In Goodman and Gilmans The
Pharmacological Basis of Therapeutics. 10th ed.
Except amlodipineRanolazine No direct effect
butmay prevent ischemia-related decline