Incoming Corium

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Incoming Corium
SEM of Corium
5 microns
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50 - 100 nm fibrils
BEFORE MILLING
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50 - 100 nm diameter
AFTER MILLING AND WASHING
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Nature
KH-122
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Donna Stauffer
KH-122
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SEM Results

• From previous work at Widener, we know ball
  milling reduces fibril sizes to as low as 70 nm.

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SEM Results

• The initial samples were fairly thick, making it
  difficult to image individual fibrils
• Note the periodicity (striped patterns)

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Donna Stauffers Thesis
AFM Results 0 min (2.5 mm)
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AFM Results 0 min (1.0 mm)
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Collagen fiber formation
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From Shanu Shahs Thesis
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2008 Technology Basis
Fibers
Nanofibrils
milling

• Time Capsule
• 1985 1988 Dartmouth College - Initial Research
• 1985 1995 Verax Corp., Lebanon, NH
• 1994 2007 Collagen Research Group, Widener U
• 150 students, professors, and colleagues have
  worked
• on protein research at Widener since 1994

Current Projects NTI seed program Osteogenics,
Inc. KIG Thermotek, Inc. Metcalf Eddy USDA
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Bovine Fibrils
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Porcine Fibrils