CARDIOVASCULAR DISEASE, GENETIC ALTERATIONS, AND GENE THERAPY

1
CARDIOVASCULAR DISEASE, GENETIC ALTERATIONS, AND
GENE THERAPY

• BY
• Mary Harrell, Farah Fevrier, Kareen Carty, Daniel
  Omotola, and Trey Palmer

2
PROBLEM

• With human gene mapping complete, does prevention
  of cardiovascular disease (CVD), the nations
  leading killer, lie within human genes?

3
PROBLEM

• Obesity
• Psychological Social Factors
• Heredity
• Aging
• Male
• Ethnicity
• Syndrome X

• Risk Factors For CVD
• Tobacco Use
• Hypertension
• High Levels of Cholesterol
• Physical inactivity
• Diabetes
• High Triglyceride Levels

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PROBLEM

• Risk Factors For CVD
• Tobacco Use
• Heredity
• High Levels of Cholesterol
• Physical Inactivity
• Diabetes
• High Triglyceride Levels

• Obesity
• Psychological Social Factors
• Hypertension
• Aging
• Male
• Ethnicity
• Syndrome X

5
BACKGROUND INFORMATION

• Facts about Cardiovascular Disease
• Mortality of CVD is 1½ times that of cancer
• Quality of life diminished for 25 of population
• Strokes account for 1/6 of all CVD
  hospitalizations
• Congestive heart failure is most frequent cause
  of hospital visits by people over 65
• Impact is far reaching

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POSSIBLE SOLUTIONS

• Gene Transfer
• Modification
• Genetically defective contractile proteins
• Myocardial cells
• Cardiac protein profile to rebuild muscle
• Enhance contractility
• Replacement
• Artherosclerosis prevention
• Regrowth
• Alternatives to invasive surgery
• Repair damaged tissue and improve heart function
  after infarction

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BEST SOLUTION

• Regrowth with the use of Stem Cells
• Proven successful on mice
• Testing on non-human primates to begin
• Angiogenesis opens up blocked vessels
• Effectiveness on cardiac muscle

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CONCLUSION

• With human gene mapping complete, does prevention
  of cardiovascular disease (CVD), the nations
  leading killer, lie within human genes?
• Push for gene therapy with stem cells on humans

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REFERENCES

• Core Concepts In Health, by Insel Roth pgs. 10,
  428-436, 446, 454, 483
• Primary site CVD/gene therapy paper
  http//oak.cats.ohiou.edu/ed170793/paper.htm
• Common viriants of most human genes
  www.ornl.gov/hgmis/publicat/hgn/v10n1/13lander.htm
  l
• Understanding DNA variations www.ornl.gov/hgmis/pu
  blicat/hgn/v10n1/06snps.html
• Explaining the human genome project
  www.nhgri.nih.gov/Policy_and_public_affairs/Commun
  ications/Publications/Maps_to_medicine/about/html

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REFERENCES

• 6. Angiogenesis www.bioportfolio.com/news/leadd
  iscovery_10.htm
• 7. Stem cells www.genome.gov/page.cfm?pag
  eID10000345
• 8. Gene clues and CVD
  www.the-aps.org/press_room?release2-19-
  02.htm
• 9. Use of stem cellls on mice www.seniors.gov/arti
  cles/0401/heartattack