Orange County Commission Report

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Orange County Commission Report March 24, 2009
Dr. Daniel P. Kelly
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Burnham Institute for Medical Research
Our Mission To reveal the fundamental causes of
disease and devise the innovative therapies of
tomorrow.

• Not-for-profit research organization
• Leader in Cancer, Neurologic, Infectious Disease
  research
• 4th among Research Institutes in NIH funding
• Now Bi-coastal!

BIMR Lake Nona Florida
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Lake Nona medical city
NEMOURS Childrens Hospital
VA MEDICAL CENTER
UCF Medical School and Burnett of Biomedcial
Science
TOWN CENTER
BURNHAM
Incubators
University of FL
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• 175,000 sq ft facility
• Completion April 2009
• 25-30 faculty planned

Burnham Institute at Lake Nona


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Collaboration Moves Discovery Science Forward at
a Rapid Pace
Sanford Child Health Center
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We are Witnessing a National Health Crisis

• Prevalence of type 2 diabetes is increasing at an
  astounding rate
• By 2025, approx. 22 million people will have type
  2 diabetes
• Care of diabetics cost over 130 billion last
  year
• Epidemic has extended to the pediatric population
  

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Why is this Happening?
2.5 million years
50 years
It is estimated that todays children will be the
first generation in history to have a shorter
life expectancy than their parents, because of
obesity.
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Diabetes is a Lethal Disease
Diabetes
Cancer

• Cardiovascular disease is the leading cause of
  death
• Diabetic heart disease is aggressive and unique
  Resistant to current treatments

CV Disease
Stroke
National Center for Health Statistics, 1998
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Merging Disciplines to Attack the Problem of
Diabetes and its Cardiac Complications
Metabolism
Cardiovascular Pathobiology
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BIMR-Lake Nona Research ProgramsCreating an
Interdisciplinary Environment

• Diabetes and Obesity Research Center

Research Programs
Metabolic Signaling and Disease
Cardiovascular Pathobiology
Obesity, Diabetes, Cancer
Heart and Vascular Disease
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Saving the Insulin Factory
Dr. Bjorn Tyrberg BIMR-La Jolla
Dr. Phil Wood Univ. Alabama
Diabetes Obesity Program
Dr. Zhen Jiang U Mass
Dr. Dev Sikder Univ. Texas
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Dr. Tod Gulick Mass Gen Harvard
Dr. Dan Kelly Washington University
Dr. Masa Komatsu Univ Alabama
How Does Obesity Cause High Blood Pressure?
Cardiovascular Disease Program
Dr. Layton Smith Vanderbilt/Scripps
Dr. Greg Roth Abbot Labs
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Advanced Technologies Drive Research

• Burnhams cutting-edge technology resources are
  unparalleled in the independent, not-for-profit
  research world.

Robotic Chemical Screening
Imaging
Metabolomics Genetics and Genomics
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UCF Partnership Training Young Scientists and
Building New Alliances

• Undergraduate/graduate student research
• Postdoctoral fellowships
• Research collaborations
• Joint Faculty appointments
• Community Outreach programs

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What Have We Accomplished to Date?

• In 18 months
• 75 scientific and administrative staff
• Two research programs launched
• High-value jobs, paying 130 average private
  sector wage in Orange County
• First to occupy medical city at Lake Nona
• Green structure is one of the three largest
  LEED certified scientific buildings in FL
• Attracted almost 40 million of NIH grants and
  research funding to Orlando
• 10M endowment for The Burnham Chemical Genomics
  Center (FL CA)

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BIMR at Lake Nona-Timeline Benchmarks
Orange completed!
FACILITIES
21 FTEs
Detailed Building Design
Temporary Space (14K sq ft)
Construction Complete (175K sq ft)
Complete Contracts
Permanent Facility Construction Begins
Mar 07
Jan 09
April 09
June 07
Jan 08
Oct 07
Apr 07
Nov 07
2008
2007
2009
Hire CFO
Sign Scientific Director
Sign VP Ops
Sign VP Ext Rel

• 3 Cores
• Chem
• Pharm
• Histology

• 5 Cores
• Phenotyping
• UHTS
• Genomics
• Metabolomics
• Vivarium

15-20 Scientists (2-3 Faculty)
Sign Core Director (1-3 Faculty)
(3-4 Faculty)
12 Faculty Signed 3/08
Establish Business Team (Purchasing HR
Facilities, IT)
PEOPLE / PROGRAMS
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Burnham at Lake Nona will be completed April,
2009 Construction is On Time On Budget
By completion, the project will have brought 85M
of funding into the local economy
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Burnham Institute Our vision for 2016

• Lead Scientists 30
• Total Employees 300
• Comprehensive Research and Technology Programs
  in the study of Diabetes, Metabolism, and
  Cardiovascular Disease
• Partnerships with UCF, local/regional Health
  Systems, UF, big Pharma
• Biotech spin-offs

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Our Sincere and Heartfelt Thanks to Orange
CountyCity of Orlando State of Florida

• For helping us accelerate our medical research
  mission!
• Institute Dedication Day October 8th
• Save the Date and Join us!