RETROVIRIDAE. Part I- RETROVIRUSES - PowerPoint PPT Presentation

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RETROVIRIDAE. Part I- RETROVIRUSES

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Title: RETROVIRIDAE. Part I- RETROVIRUSES


1
RETROVIRIDAE. Part I- RETROVIRUSES
  • PETER H. RUSSELL, BVSc, PhD, FRCPath, MRCVS
  • Department of Pathology and Infectious Diseases,
    The Royal Veterinary College,
  • Royal College Street,
  • London NW1 OTU.
  • E-mail Web site

2
ObjectiveStudents should be able to
  • define the importance of reverse transcriptase in
    replication and chromosomal integration.
  • explain subgroup, endogenous viruses, oncogenes
    and transformation, how lability leads to either
    horizontal transmission by close contact/blood or
    vertical transmission.
  • describe the clinical signs of FeLV, the
    diagnostic ELISA test for FeLV and test and
    removal schemes.
  • describe in outline the pathogenesis and control
    of Bovine Leukosis virus and sheep Pulmonary
    Adenomatosis

3
Classification of Retroviridae
  • the genera include these veterinary viruses

4
STRUCTURE
5
Physicochemical properties
  • The virus only survives for a few hours outside
    the host.
  • Small amounts of virus are excreted by the host
    and infection requires either close contact, e.g.
    mutual grooming, blood transfer or vertical
    transmission (see later)

6
Transformation and oncogenesis
7
Transfection, Research
8
Detection
  • Because leukaemia viruses cause no cytopathic
    effect in tissue culture they have been detected
    by EM or by IIF .

9
Cell tropism in vivo
  • They grow in rapidly-dividing cells eg bone
    marrow.

10
FELINE LEUKAEMIA VIRUS (FeLV)
  • FeLV is one causative agent of feline
    lymphosarcoma and leukaemia, which are the most
    important and common tumours of cats. The same
    tumours sometimes occur without FeLV,
    particularly in cats aged over 7 years.

11
FELINE LEUKAEMIA VIRUS (FeLV)
  • Pathogenesis

12
FELINE LEUKAEMIA VIRUS (FeLV)
  • Clinical signs

13
FELINE LEUKAEMIA VIRUS (FeLV)
  • Epidemiology

14
FELINE LEUKAEMIA VIRUS (FeLV)
  • Diagnosis of FeLV

15
FELINE LEUKAEMIA VIRUS (FeLV)
  • Control

16
SHEEP PULMONARY ADENOMATOSIS (SPA)
  • Virus Retrovirus particles can be seen by EM in
    the tumour cells of affected sheep. The virus
    cannot be grown in culture.

17
SHEEP PULMONARY ADENOMATOSIS (SPA)
  • DiagnosisNo serological test nor virus isolation
    is possible. Clinical symptoms. Nasal fluid
    discharges when the sheep is up-ended (the
    wheelbarrow test). At post mortem the tumour is
    fawn-grey in colour but may be obscured by
    secondary infection with oedema and/or pneumonia.

18
AVIAN LEUKOSIS VIRUS
19
BOVINE LEUKOSIS VIRUS (BLV)
  • Notifiable disease.
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