The Metabotropic GABAB Receptors

1
The Metabotropic GABAB Receptors
2
Advantages of Neuromodulation ( complex
biochemical mechanisms)

• Signal amplification e.g. 1 molecule of NM can
  cause production of thousands of molecules of
  ATP.
• Space amplification the signal spreads out in
  space from the site of the receptor.
• Time amplification the signal can last a long
  time.

3
Fig. 13.2
4
Levitan Kaczmarek Fig. 11-7
5
Fig. 13.2
6
Fig. 13.3
7
Bear Fig. 6.27
8
Fig. 13.3
9
(in cerebellar granule cells)
Fig. 13.5a,b
10
( 100 mM NE)
Fig. 13.6
11
Fig. 13.8
12
Fig. 3.7
13
Fig. 13.15