Proteins Determines Cell Structure and Function

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Proteins Determines Cell Structure and Function

• Unique protein expression
• by each cell type.
• Proteins are 60 of
• dry mass of living cell.
• Proteins determine function.

http//www.library.csi.cuny.edu/davis/Bioinfo_326
/lectures/centralDogmaProteins/centralDogma.html
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The Central Dogma
DNA RNA
Protein
Symptomes
(Phenotype)
Cells express different subset of the genes in
different tissues and under different conditions.
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The Central Dogma of Molecular Biology
Replication- DNA duplication
Transcription- RNA synthesis
Nucleus
Cytoplasm
Translation- Protein synthesis
http//www.accessexcellence.com/AB/GG/central.html
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New Central Dogma
1 gene
Many mRNA transcripts
Many protein types
5
The BIG Goal

• The greatest challenge, however, is analytical.
  Deeper biological insight
• is likely to emerge from examining
• datasets with scores of samples.
• Eric Lander, array of hope Nat.
  Gen.
• volume 21 supplement pp 3 - 4,
  1999.

Bio-informatics Provide methodologies for
elucidating biological knowledge from biological
data.