Viral Immunity

1
Viral Immunity

• Cellular
• Th1 provides interleukin stimulation (IL2, TNFß,
  INF?)
• Tc kills infected cell via MHC I

• Humoral
• Th2 provides interleukin stimulation (IL2,4,5,6,
  10)
• B cells differentiate to plasma cells and produce
  IgM, IgG, IgA, etc.

2
T Help
Exogenous Antigen
Th ? Lymphokines ? Tc cell or ? B cell
APC Antigen Presenting Cell Macrophage,
Dendritic Cell
3
Antiviral Antibody Responses Neutralization Agglut
ination Virolysis ADCC
4
T Killing
Viral antigens sent to cell surface
Tc recognition of the viral antigens
(Tc)
? Cell killing
5
Apoptosis
6
Interferon Induction by dsRNA
Toll like Receptor 3
7
Interferon Signaling and gene activation in
cells ISRE interferon stimulated response
element GAS Interferon gamma activated site
8
The Antiviral State Virus Inhibitors RNAse
L PKR OAS ..many others
9
Showing the problem for viral replication in
interferon-induced antiviral state
10
How some viruses inhibit interferon or the
antiviral state